血管活性肠肽

血管活性肠肽Vasoactive intestinal peptide),常简称VIP,属于一种可促进肠道血管活性英语vasoactive肽类激素,由28个氨基酸残基组成。本蛋白属于升糖素/胰泌素超家族英语protein superfamily,为第二型G蛋白偶联受体配体[5]。VIP在许多脊椎动物身上皆存在,包含英语Gut (zoology)胰脏,以及下视丘视上核英语suprachiasmatic nuclei[6][7][8]。VIP能刺激心脏收缩力英语contractility血管舒张、增加糖原分解、降低动脉血压,以及促进气管、胃、胆囊平滑肌舒张。在人类体内,该蛋白的编码基因为“VIP[9]

血管活性肠肽
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名VIP;, vasoactive intestinal peptide, PHM27
外部IDOMIM192320 MGI98933 HomoloGene2539 GeneCardsVIP
基因位置(人类
6号染色体
染色体6号染色体[1]
6号染色体
血管活性肠肽的基因位置
血管活性肠肽的基因位置
基因座6q25.2起始152,750,797 bp[1]
终止152,759,765 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_003381
​NM_194435

NM_011702
​NM_001313969

蛋白序列

NP_003372
​NP_919416

基因位置​(UCSC)Chr 6: 152.75 – 152.76 MbChr 10: 5.59 – 5.6 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

VIP在血中的半衰期(t½)约两分钟[10]

参考文献

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000146469 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000019772 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H. Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments. Biochimica et Biophysica Acta. May 2011, 1814 (5): 724–30. PMID 21439408. doi:10.1016/j.bbapap.2011.03.009. 
  6. ^ Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R. PACAP and VIP signaling in chondrogenesis and osteogenesis. Peptides. April 2015, 66: 51–7. PMID 25701761. doi:10.1016/j.peptides.2015.02.001. 
  7. ^ Delgado M, Ganea D. Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions. Amino Acids. July 2013, 45 (1): 25–39. PMC 3883350 . PMID 22139413. doi:10.1007/s00726-011-1184-8. 
  8. ^ Fahrenkrug J. VIP and PACAP. Results and Problems in Cell Differentiation. 2010-01-01, 50: 221–34. PMID 19859678. doi:10.1007/400_2009_24. 
  9. ^ Hahm SH, Eiden LE. Cis-regulatory elements controlling basal and inducible VIP gene transcription. Annals of the New York Academy of Sciences. December 1998, 865: 10–26. PMID 9927992. 
  10. ^ Henning RJ, Sawmiller DR. Vasoactive intestinal peptide: cardiovascular effects. Cardiovascular Research. January 2001, 49 (1): 27–37. PMID 11121793. 

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