MASP-1

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
標識
代號	MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
擴展標識	遺傳學：600521 同源基因：89143 GeneCards: MASP1 Gene
EC編號	3.4.21.-
基因本體論描述
分子功能	· serine-type endopeptidase activity; · calcium ion binding; · protein binding; · peptidase activity; · protein homodimerization activity; · calcium-dependent protein binding;
細胞成分	· extracellular region; · extracellular space;
生物過程	· complement activation, lectin pathway; · proteolysis; · receptor-mediated endocytosis; · complement activation; · innate immune response; · negative regulation of complement activation;
	Sources: Amigo / QuickGO
直系同源體
物種	人類
Entrez	5648
Ensembl	ENSG00000127241
UniProt	P48740
mRNA序列	NM_001031849
蛋白序列	NP_001027019
基因位置	Chr 3:; 187.22 – 187.29 Mb
PubMed查詢	[1]
	閱; 論; 編;

甘露糖結合凝集素絲氨酸蛋白酶1 （Mannan-binding lectin serine protease 1，也被稱為 甘露糖相關絲氨酸蛋白酶1，mannose-associated serine protease 1，縮寫MASP-1）是由人類基因 MASP1 編碼的一種酶。^[1]^[2]^[3]

MASP-1參與補體系統的凝集素途徑，負責的切割C4和C2形成C4b2a，作為C3-轉化酶參與下一步的反應。^[4]

另見

甘露聚糖結合凝集素

參考文獻

^ A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.
^ Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.
^ Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).
^ Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始內容存檔於2009-01-09）.

外部連結

醫學主題詞表（MeSH）：MASP+Proteases

MASP-1引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。

[pmid8240317-1] A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.

[pmid8018603-2] Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.

[entrez-3] Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).

[pmid10946292-4] Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始內容存檔於2009-01-09）.

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