MASP-1

Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
标识
代号	MASP1; 3MC1; CRARF; CRARF1; MAP1; MASP; MASP3; MAp44; PRSS5; RaRF
扩展标识	遗传学：600521 同源基因：89143 GeneCards: MASP1 Gene
EC编号	3.4.21.-
基因本体论描述
分子功能	· serine-type endopeptidase activity; · calcium ion binding; · protein binding; · peptidase activity; · protein homodimerization activity; · calcium-dependent protein binding;
细胞成分	· extracellular region; · extracellular space;
生物过程	· complement activation, lectin pathway; · proteolysis; · receptor-mediated endocytosis; · complement activation; · innate immune response; · negative regulation of complement activation;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	5648
Ensembl	ENSG00000127241
UniProt	P48740
mRNA序列	NM_001031849
蛋白序列	NP_001027019
基因位置	Chr 3:; 187.22 – 187.29 Mb
PubMed查询	[1]
	查; 论; 编;

甘露糖结合凝集素丝氨酸蛋白酶1 （Mannan-binding lectin serine protease 1，也被称为 甘露糖相关丝氨酸蛋白酶1，mannose-associated serine protease 1，缩写MASP-1）是由人类基因 MASP1 编码的一种酶。^[1]^[2]^[3]

MASP-1参与补体系统的凝集素途径，负责的切割C4和C2形成C4b2a，作为C3-转化酶参与下一步的反应。^[4]

另见

甘露聚糖结合凝集素

参考文献

^ A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.
^ Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.
^ Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).
^ Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始内容存档于2009-01-09）.

外部链接

医学主题词表（MeSH）：MASP+Proteases

MASP-1引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

[pmid8240317-1] A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum. Biochemical and Biophysical Research Communications. Oct 1993, 196 (2): 1003–9. PMID 8240317. doi:10.1006/bbrc.1993.2349.

[pmid8018603-2] Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. International Immunology. Apr 1994, 6 (4): 665–9. PMID 8018603. doi:10.1093/intimm/6.4.665.

[entrez-3] Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor).

[pmid10946292-4] Proteolytic activities of two types of mannose-binding lectin-associated serine protease. Journal of Immunology. Sep 2000, 165 (5): 2637–42 [2016-11-24]. PMID 10946292. doi:10.4049/jimmunol.165.5.2637. （原始内容存档于2009-01-09）.

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