CD132

CD132
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2B5I、2ERJ、3BPL、3QAZ、3QB7、4GS7
识别号
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相关疾病
	X性联严重复合免疫缺乏症、combined immunodeficiency, X-linked
为以下药物的标靶
	denileukin diftitox
基因位置（人类）
染色体	X染色体
终止	71,112,108 bp
基因位置（小鼠）
染色体	小鼠X染色体
终止	100,311,861 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• interleukin-7 receptor activity; • interleukin-2 receptor activity; • 血浆蛋白结合; • cytokine receptor activity; • interleukin-4 receptor activity; • interleukin-2 binding; • cytokine binding; • interleukin-15 receptor activity;
细胞组分	• integral component of membrane; • 膜; • 细胞膜; • integral component of plasma membrane; • external side of plasma membrane; • 核内体; • 细胞质基质; • cell surface; • receptor complex;
生物学过程	• MAPK cascade; • 免疫反应; • viral process; • 信号转导; • interleukin-2-mediated signaling pathway; • interleukin-4-mediated signaling pathway; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • 分子功能调控; • cytokine-mediated signaling pathway; • interleukin-21-mediated signaling pathway; • positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
直系同源
	3561
	16186
	ENSG00000147168
	ENSMUSG00000031304
	P31785
	P34902
	NM_000206
	NM_013563; NM_001308535
	NP_000197
	NP_001295464; NP_038591
	维基数据
查看/编辑人类	查看/编辑小鼠

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4^[7]、IL-7^[8]、IL-9、IL-15^[9]和IL-21的受体。γ_c是I型细胞因子受体家族中的一种糖蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

参考文献

^ 與CD132相關的疾病；在維基數據上查看/編輯參考.
^ 對Interleukin 2 receptor subunit gamma起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.
^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.
^ Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440  . PMID 7641685.

延伸阅读

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Kalman L, Lindegren ML, Kobrynski L, Vogt R, Hannon H, Howard JT, Buckley R. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review. Genet Med. 2004, 6 (1): 16–26. PMID 14726805. doi:10.1097/01.GIM.0000105752.80592.A3.
Ellery JM, Nicholls PJ. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 2002, 13 (1): 27–40. PMID 11750878. doi:10.1016/S1359-6101(01)00023-5.
Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K. Cloning of the gamma chain of the human IL-2 receptor. Science. July 1992, 257 (5068): 379–82. PMID 1631559. doi:10.1126/science.1631559.
Burton J, Goldman CK, Rao P, Moos M, Waldmann TA. Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7329–33. PMC 54737  . PMID 1976256. doi:10.1073/pnas.87.18.7329.
Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S. Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA. Proc. Natl. Acad. Sci. U.S.A. March 1990, 87 (6): 2379–83. PMC 53690  . PMID 2315327. doi:10.1073/pnas.87.6.2379.
Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. September 1988, 335 (6189): 445–8. PMID 2843775. doi:10.1038/335445a0.
Bamborough P, Hedgecock CJ, Richards WG. The interleukin-2 and interleukin-4 receptors studied by molecular modelling. Structure. 1995, 2 (9): 839–51. PMID 7529123. doi:10.1016/S0969-2126(94)00085-9.
Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Hum. Genet. October 1995, 96 (4): 427–32. PMID 7557965. doi:10.1007/BF00191801.
Pepper AE, Buckley RH, Small TN, Puck JM. Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency. Am. J. Hum. Genet. September 1995, 57 (3): 564–71. PMC 1801277  . PMID 7668284.
Ohbo K, Takasawa N, Ishii N, Tanaka N, Nakamura M, Sugamura K. Functional analysis of the human interleukin 2 receptor gamma chain gene promoter. J. Biol. Chem. March 1995, 270 (13): 7479–86. PMID 7706294. doi:10.1074/jbc.270.13.7479.
Puck JM, Pepper AE, Bédard PM, Laframboise R. Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency. J. Clin. Invest. February 1995, 95 (2): 895–9. PMC 295580  . PMID 7860773. doi:10.1172/JCI117740.
DiSanto JP, Rieux-Laucat F, Dautry-Varsat A, Fischer A, de Saint Basile G. Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc. Natl. Acad. Sci. U.S.A. September 1994, 91 (20): 9466–70. PMC 44833  . PMID 7937790. doi:10.1073/pnas.91.20.9466.
Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science. November 1994, 266 (5187): 1042–5. PMID 7973658. doi:10.1126/science.7973658.
Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, Konno T, Maeda M, Uchiyama T, Sugamura K. Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency. J. Immunol. August 1994, 153 (3): 1310–7. PMID 8027558.
Johnson K, Choi Y, Wu Z, Ciardelli T, Granzow R, Whalen C, Sana T, Pardee G, Smith K, Creasey A. Soluble IL-2 receptor beta and gamma subunits: ligand binding and cooperativity. Eur. Cytokine Netw. 1994, 5 (1): 23–34. PMID 8049354.
Markiewicz S, Subtil A, Dautry-Varsat A, Fischer A, de Saint Basile G. Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing. Genomics. May 1994, 21 (1): 291–3. PMID 8088810. doi:10.1006/geno.1994.1265.
Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. December 1993, 262 (5141): 1874–7. PMID 8266076. doi:10.1126/science.8266076.

外部链接

医学主题词表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit

[1] 與CD132相關的疾病；在維基數據上查看/編輯參考.

[2] 對Interleukin 2 receptor subunit gamma起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8266078-7] Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.

[pmid8266077-8] Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.

[pmid7641685-9] Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440  . PMID 7641685.

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