CD44
CD44,在人體內是一種由11號染色體上的CD44基因編碼的細胞表面黏附分子,化學本質是糖蛋白,屬於一類分化簇(CD)[5][6]。CD44是一種常用的幹細胞表面標記物,同時在人體內也參與淋巴細胞活化、循環,以及歸巢、惡性腫瘤的發生及轉移等過程[7][6]。
遺傳學與分子生物學
CD44的基因位於人11號染色體上,具有可變剪接現象。已有研究證明,不同轉錄本轉譯的CD44具有不同的功能,分子量從85到200kD不等,其中最經典的標準CD44分子(sCD44)是從造血細胞中分離出來的,分子量約爲85-90kD,由外顯子1-5和16-20組合而成。CD44分子在人體內廣泛分佈,並參與許多生物學過程,比如淋巴細胞的活化、再循環(recirculation),以及歸巢(homing)、造血過程、惡性腫瘤的發生與轉移等[8][6][9]。
CD44蛋白由一條肽鏈組成,膜外結構域位於肽鏈一端,一個膜側翼區與之相連,另有一個穿膜結構域和一個位於細胞膜靠細胞質一側的尾部[10]。
應用
在生物學和醫學研究中,CD44可用作幹細胞標記物,用於幹細胞的鑑定[7]。許多惡性腫瘤細胞中CD44的表達上調,比如卵巢癌[11]。另外,CD44可能和惡性腫瘤的發生和轉移有關,在相關過程中發揮一定的作用,比如已有證據表明CD44與頭頸鱗狀細胞癌的發展有關[6]。
參見
參考
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000026508 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000005087 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, Fabre JW, Anstee DJ. The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene. Immunology. May 1988, 64 (1): 37–43. PMC 1385183 . PMID 2454887.
- ^ 6.0 6.1 6.2 6.3 CD44. GeneCards. [2018-07-09]. (原始內容存檔於2018-07-09).
- ^ 7.0 7.1 Morath, I.; Hartmann, T.N.; Orian-Rousseau, V. CD44: More than a mere stem cell marker. The International Journal of Biochemistry & Cell Biology. 2016, 81: 166–173. ISSN 1357-2725. doi:10.1016/j.biocel.2016.09.009.
- ^ CD44. NCBI. [2018-07-09]. (原始內容存檔於2018-08-20).
- ^ Senbanjo, Linda T.; Chellaiah, Meenakshi A. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Frontiers in Cell and Developmental Biology. 2017, 5. ISSN 2296-634X. doi:10.3389/fcell.2017.00018.
- ^ Naor, David; Sionov, Ronit Vogt; Ish-Shalom, Dvorah. CD44: Structure, Function and Association with the Malignant Process 71: 241–319. 1997. ISSN 0065-230X. doi:10.1016/S0065-230X(08)60101-3.
- ^ Sillanpää S, Anttila MA, Voutilainen K, Tammi RH, Tammi MI, Saarikoski SV, Kosma VM. CD44 expression indicates favorable prognosis in epithelial ovarian cancer. Clinical Cancer Research. Nov 2003, 9 (14): 5318–24 [2018-07-09]. PMID 14614016. (原始內容存檔於2015-09-27).
- ^ Telen MJ, Udani M, Washington MK, Levesque MC, Lloyd E, Rao N. A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J. Biol. Chem. March 1996, 271 (12): 7147–53. PMID 8636151. doi:10.1074/jbc.271.12.7147.