醋哌隆

化合物

醋哌隆INN:aceperone)是丁酰苯類的精神安定藥。它是楊森製藥於1960年代開發的一種α-去甲腎上腺素阻斷藥物。[1]

醋哌隆
臨床資料
其他名稱Acetabuton、R 3248
ATC碼
  • 未分配
識別資訊
  • N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
CAS號807-31-8
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C24H29FN2O2
摩爾質量396.51 g·mol−1
3D模型(JSmol英語JSmol
熔點97至100 °C(207至212 °F) [1]
  • Fc1ccc(cc1)C(=O)CCCN3CCC(c2ccccc2)(CC3)CNC(=O)C
  • InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28)
  • Key:VDGZERMDPAAZEJ-UHFFFAOYSA-N

醋哌隆已被用作學習生化基礎研究的工具。儘管醋哌隆本身不會阻礙學習,但在低於影響一般行為的劑量下,它會阻礙動物的一種注意力機制,該機制在學習視覺判別任務時幫助動物「調諧」到相關的視覺維度。[2][3][4]

參考資料

  1. ^ 1.0 1.1 BE 606849,Janssen PA,「Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines.」,發表於1961 
  2. ^ Ridley RM, Haystead TA, Baker HF, Crow TJ. A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade. Pharmacology, Biochemistry, and Behavior. June 1981, 14 (6): 849–55. PMID 6114497. S2CID 35341802. doi:10.1016/0091-3057(81)90373-7. 
  3. ^ Baker HF, Ridley RM, Haystead TA, Crow TJ. Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and colour discrimination and on an alternation task. Pharmacology, Biochemistry, and Behavior. May 1983, 18 (5): 701–4. PMID 6222386. S2CID 7905046. doi:10.1016/0091-3057(83)90009-6. 
  4. ^ Scraggs PR, Ridley RM. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology. March 1979, 62 (1): 41–5. PMID 155838. S2CID 38197514. doi:10.1007/BF00426033.