醋哌隆

化合物

醋哌隆INN:aceperone)是丁酰苯类的精神安定药。它是杨森制药于1960年代开发的一种α-去甲肾上腺素阻断药物。[1]

醋哌隆
临床资料
其他名称Acetabuton、R 3248
ATC码
  • 未分配
识别信息
  • N-({1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl}methyl)acetamide
CAS号807-31-8
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C24H29FN2O2
摩尔质量396.51 g·mol−1
3D模型(JSmol英语JSmol
熔点97至100 °C(207至212 °F) [1]
  • Fc1ccc(cc1)C(=O)CCCN3CCC(c2ccccc2)(CC3)CNC(=O)C
  • InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28)
  • Key:VDGZERMDPAAZEJ-UHFFFAOYSA-N

醋哌隆已被用作学习生化基础研究的工具。尽管醋哌隆本身不会阻碍学习,但在低于影响一般行为的剂量下,它会阻碍动物的一种注意力机制,该机制在学习视觉判别任务时帮助动物“调谐”到相关的视觉维度。[2][3][4]

参考资料

  1. ^ 1.0 1.1 BE 606849,Janssen PA,“Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines.”,发表于1961 
  2. ^ Ridley RM, Haystead TA, Baker HF, Crow TJ. A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade. Pharmacology, Biochemistry, and Behavior. June 1981, 14 (6): 849–55. PMID 6114497. S2CID 35341802. doi:10.1016/0091-3057(81)90373-7. 
  3. ^ Baker HF, Ridley RM, Haystead TA, Crow TJ. Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and colour discrimination and on an alternation task. Pharmacology, Biochemistry, and Behavior. May 1983, 18 (5): 701–4. PMID 6222386. S2CID 7905046. doi:10.1016/0091-3057(83)90009-6. 
  4. ^ Scraggs PR, Ridley RM. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology. March 1979, 62 (1): 41–5. PMID 155838. S2CID 38197514. doi:10.1007/BF00426033.