VCAM-1

VCAM-1
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1IJ9、1VCA、1VSC
识别号
别名	VCAM1；, CD106, INCAM-100, vascular cell adhesion molecule 1
外部ID	OMIM：192225 MGI：98926 HomoloGene：838 GeneCards：VCAM1
基因位置（人类）
染色体	1号染色体
终止	100,739,045 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	115,923,337 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• primary amine oxidase activity; • integrin binding; • cell adhesion molecule binding;
细胞组分	• integral component of membrane; • 高尔基体; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; • 膜; • 丝状伪足; • 细胞膜; • apical part of cell; • 微绒毛; • cell surface; • 早期内吞体; • 内质网; • podosome; • 肌膜; • 外排体; • external side of plasma membrane; • 细胞外空间; • integral component of plasma membrane;
生物学过程	• leukocyte cell-cell adhesion; • response to ionizing radiation; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • response to hypoxia; • response to nutrient; • interferon-gamma-mediated signaling pathway; • cellular response to tumor necrosis factor; • response to nicotine; • 老化; • response to zinc ion; • extracellular matrix organization; • amine metabolic process; • response to lipopolysaccharide; • 细胞粘附; • acute inflammatory response; • positive regulation of T cell proliferation; • membrane to membrane docking; • regulation of immune response; • leukocyte tethering or rolling; • cell chemotaxis; • B cell differentiation; • cellular response to vascular endothelial growth factor stimulus; • cell-matrix adhesion; • viral process; • response to ethanol; • calcium-mediated signaling using intracellular calcium source; • chronic inflammatory response; • cell-cell adhesion; • cytokine-mediated signaling pathway; • heterotypic cell-cell adhesion; • innervation; • cardiac neuron differentiation; • cell-cell adhesion in response to extracellular stimulus; • cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
直系同源
	7412
	22329
	ENSG00000162692
	ENSMUSG00000027962
	P19320
	P29533
	NM_080682; NM_001078; NM_001199834
	NM_011693
	NP_001069; NP_001186763; NP_542413
	NP_035823
	维基数据
查看/编辑人类	查看/编辑小鼠

VCAM-1（Vascular cell adhesion protein 1（I型血管细胞黏附蛋白）），又称CD106，是一种细胞黏附蛋白，在人体内由VCAM-1基因编码，属于一种唾液酸糖蛋白^[5]。

结构

VCAM-1含有6个或7个免疫球蛋白结构域，属于免疫球蛋白蛋白超家族（英语：Protein superfamily）（IgSF）。于人体内存在两个由可变剪接产生的转录本^[6]。

功能与分布

VCAM-1参与淋巴细胞—内皮细胞间黏附过程和细胞间信号识别过程，能在免疫应答中促进淋巴细胞向炎症区迁移^[7]。淋巴细胞、软骨细胞等细胞中都含有VCAM-1，血管内皮细胞在受到细胞因子刺激后也会表达VCAM-1蛋白^[6]^[8]。一些间充质干细胞亚群细胞表面表达CD106（VCAM-1）^[9]。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.
^ ^6.0 ^6.1 Entrez Gene: VCAM1 vascular cell adhesion molecule 1.
^ VCAM1. Uniprot. [2018-01-10]. （原始内容存档于2017-10-03）.
^ Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305.
^ ZX Yang; et al. CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8(3):e59354.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Cybulsky_1991-5] Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.

[NCBI-6] 6.0 ^6.1 Entrez Gene: VCAM1 vascular cell adhesion molecule 1.

[7] VCAM1. Uniprot. [2018-01-10]. （原始内容存档于2017-10-03）.

[8] Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305.

[9] ZX Yang; et al. CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8(3):e59354.

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