C5a受体

C5a受体
识别号
别名	C5AR1；, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
外部ID	OMIM：113995 MGI：88232 HomoloGene：20413 GeneCards：C5AR1
基因位置（人类）
染色体	19号染色体
终止	47,322,066 bp
基因位置（小鼠）
染色体	小鼠7号染色体
终止	15,993,465 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• complement component C5a binding; • signal transducer activity; • complement receptor activity; • complement component C5a receptor activity; • G protein-coupled receptor activity;
细胞组分	• integral component of membrane; • 膜; • 细胞膜; • apical part of cell; • integral component of plasma membrane; • cell surface; • basolateral plasma membrane; • cytoplasmic vesicle; • secretory granule membrane;
生物学过程	• negative regulation of neuron apoptotic process; • positive regulation of epithelial cell proliferation; • mRNA transcription by RNA polymerase II; • activation of phospholipase C activity; • neutrophil chemotaxis; • positive regulation of angiogenesis; • 趋化性; • cellular defense response; • response to lipopolysaccharide; • animal organ regeneration; • 免疫反应; • response to peptidoglycan; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of neutrophil chemotaxis; • complement receptor mediated signaling pathway; • sensory perception of chemical stimulus; • positive regulation of vascular endothelial growth factor production; • cell proliferation in hindbrain; • positive regulation of macrophage chemotaxis; • 信号转导; • defense response to Gram-positive bacterium; • 细胞凋亡; • regulation of complement activation; • inflammatory response; • phospholipase C-activating G protein-coupled receptor signaling pathway; • neutrophil degranulation; • leukocyte migration; • cell chemotaxis; • positive regulation of cytosolic calcium ion concentration; • G protein-coupled receptor signaling pathway; • complement component C5a signaling pathway; • 认知; • regulation of astrocyte activation; • presynapse organization; • regulation of amyloid-beta clearance; • regulation of tau-protein kinase activity; • regulation of microglial cell activation;
	Sources:Amigo / QuickGO
直系同源
	728
	12273
	ENSG00000197405
	ENSMUSG00000049130
	P21730
	P30993
	NM_001736
	NM_001173550; NM_007577
	NP_001727
	NP_001167021; NP_031603
	维基数据
查看/编辑人类	查看/编辑小鼠

C5a受体（英语：C5a receptor或称补体成分5a受体1，complement component 5a receptor 1，C5AR1或CD88，Cluster of Differentiation 88）是一种与补体C5a（英语：Complement component 5a）相结合的G蛋白偶联受体^[5]。

细胞

C5a受体表达于以下细胞：^[6]

粒细胞
单核细胞
树突状细胞
肝癌细胞Hep G2以及由其衍生的肝癌细胞系
星形胶质细胞
小胶质细胞

另见

补体成分5a（英语：Complement component 5a）

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197405 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049130 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994, 12: 775–808. PMID 8011297. doi:10.1146/annurev.iy.12.040194.004015.
^ Klos A, Wende E, Wareham KJ, Monk PN. International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 2013, 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223.

延伸阅读

Sengeløv H. Complement receptors in neutrophils.. Crit. Rev. Immunol. 1996, 15 (2): 107–31. PMID 8573284.
Beil WJ, Schulz M, Wefelmeyer U. Mast cell granule composition and tissue location--a close correlation.. Histol. Histopathol. 2001, 15 (3): 937–46. PMID 10963136.
Yamamoto T. Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.. Pathol. Int. 2007, 57 (1): 1–11. PMID 17199736. doi:10.1111/j.1440-1827.2007.02049.x.
Bao L, Gerard NP, Eddy RL; et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.. Genomics. 1992, 13 (2): 437–40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T.
Gerard NP, Gerard C. The chemotactic receptor for human C5a anaphylatoxin.. Nature. 1991, 349 (6310): 614–7. PMID 1847994. doi:10.1038/349614a0.
Boulay F, Mery L, Tardif M; et al. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.. Biochemistry. 1991, 30 (12): 2993–9. PMID 2007135. doi:10.1021/bi00226a002.
Wahl SM, Allen JB, Gartner S; et al. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.. J. Immunol. 1989, 142 (10): 3553–9. PMID 2541200.
Foreman KE, Vaporciyan AA, Bonish BK; et al. C5a-induced expression of P-selectin in endothelial cells.. J. Clin. Invest. 1994, 94 (3): 1147–55. PMC 295185  . PMID 7521884. doi:10.1172/JCI117430.
Giannini E, Brouchon L, Boulay F. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.. J. Biol. Chem. 1995, 270 (32): 19166–72. PMID 7642584. doi:10.1074/jbc.270.32.19166.
Buhl AM, Osawa S, Johnson GL. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.. J. Biol. Chem. 1995, 270 (34): 19828–32. PMID 7649993. doi:10.1074/jbc.270.34.19828.
Wennogle LP, Conder L, Winter C; et al. Stabilization of C5a receptor--G-protein interactions through ligand binding.. J. Cell. Biochem. 1994, 55 (3): 380–8. PMID 7962171. doi:10.1002/jcb.240550316.
Gerard NP, Bao L, Xiao-Ping H; et al. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.. Biochemistry. 1993, 32 (5): 1243–50. PMID 8383526. doi:10.1021/bi00056a007.
Ames RS, Li Y, Sarau HM; et al. Molecular cloning and characterization of the human anaphylatoxin C3a receptor.. J. Biol. Chem. 1996, 271 (34): 20231–4. PMID 8702752. doi:10.1074/jbc.271.34.20231.
Werfel T, Zwirner J, Oppermann M; et al. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 1996, 157 (4): 1729–35. PMID 8759762.
Höpken UE, Lu B, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection.. Nature. 1996, 383 (6595): 86–9. PMID 8779720. doi:10.1038/383086a0.
Chen Z, Zhang X, Gonnella NC; et al. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 1998, 273 (17): 10411–9. PMID 9553099. doi:10.1074/jbc.273.17.10411.
Floreani AA, Heires AJ, Welniak LA; et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 1998, 160 (10): 5073–81. PMID 9590258.
Ottonello L, Corcione A, Tortolina G; et al. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.. J. Immunol. 1999, 162 (11): 6510–7. PMID 10352266.
Kohleisen B, Shumay E, Sutter G; et al. Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.. AIDS. 2000, 13 (17): 2331–41. PMID 10597774. doi:10.1097/00002030-199912030-00004.
Monk PN, Scola A-M, Madala P, Fairlie DP. Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology. 2007, 152 (4): 429–48. PMC 2050825  . PMID 17603557. doi:10.1038/sj.bjp.0707332.

外部链接

Anaphylatoxin Receptors: C5a. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2014-04-07）.
医学主题词表（MeSH）：C5a+receptors

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197405 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049130 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8011297-5] Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994, 12: 775–808. PMID 8011297. doi:10.1146/annurev.iy.12.040194.004015.

[pmid=_23383423-6] Klos A, Wende E, Wareham KJ, Monk PN. International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 2013, 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223.

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