3-碘类甲腺质
化合物
3-类甲腺质，英文：3-Iodothyronamine（T1AM）是一种内源性类甲腺质。T1AM是痕量胺相关受体TAAR1（TAR1, TA1）的高亲和力配体，而TAAR1是一种G蛋白偶联受体。[1][2]T1AM是迄今为止发现的最有效的内源性TAAR1激动剂。[3]T1AM对TAAR1的激活导致产生大量cAMP。这种影响伴随体温和心输出量的下降。[4]这种关系不是典型的内分泌系统关系，表明TAAR1活性可能不会与某些组织中的G蛋白发生偶联，或T1AM可能与其他受体亚型相互作用。[3]
| 3-碘类甲腺质 | |
|---|---|
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| IUPAC名 4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol | |
| 别名 | T1AM |
| 识别 | |
| CAS号 | 712349-95-6 
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| PubChem | 9950514 |
| ChemSpider | 8126125 |
| SMILES |
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| InChI |
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| InChIKey | XIINYOJWNGOUPF-UHFFFAOYAJ |
| 性质 | |
| 化学式 | C14H14INO2 |
| 摩尔质量 | 355.17 g/mol g·mol⁻¹ |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
参见
- <i id="mwKg">O-</i>苯基-3-碘酪胺
- 微量胺
参考
- ^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.
- ^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
- ^ 3.0 3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.
- ^ New compound may act to keep thyroid activity in check. [2008-05-30]. （原始内容存档于2021-02-27）.
- ^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.