甲苯米定

化合物

甲苯米定(英語:Xylamidine)是一种含氮有机化合物,分子式C19H24N2O2,属于5-HT1A受体拮抗剂,无法通过血腦屏障[1][2]。它可以3-甲氧基苯酚为原料经多步反应合成得到。[3]

甲苯米定
臨床資料
ATC碼
  • 未分配
识别信息
  • N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
CAS号6443-50-1  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C19H24N2O2
摩尔质量312.41 g·mol−1
3D模型(JSmol英语JSmol
  • CC1=CC(=CC=C1)CC(=NCC(C)OC2=CC=CC(=C2)OC)N
  • InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21) ☒N
  • Key:JRYTUFKIORWTNI-UHFFFAOYSA-N ☒N

参考文献

  1. ^ Fuller RW, Kurz KD, Mason NR, Cohen ML. Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67. European Journal of Pharmacology. June 1986, 125 (1): 71–7. PMID 3732393. doi:10.1016/0014-2999(86)90084-1. 
  2. ^ Dedeoğlu A, Fisher LA. Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. The Journal of Pharmacology and Experimental Therapeutics. December 1991, 259 (3): 1027–34. PMID 1762059. 
  3. ^ The Wellcome Foundation. Werkwijze voor het bereiden van amidinen of daarvan afgeleide zuur-additiezouten, die werkzaam zijn als antagonisten van 5-hydroxytryptamine, en van farmaceutische preparaten, die ten minste een van deze verbindingen als werkzame verbinding bevatten(荷兰文), 1965. NL6508754A.

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