孕烷醇酮

孕烷醇酮
	IUPAC名; 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
別名	Eltanolone; 5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; 3α,5β-Tetrahydroprogesterone; 3α,5β-THP; 3α-Hydroxy-5β-tetrahydroprogesterone
識別
CAS號	128-20-1
PubChem	31402
ChemSpider	29132
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C;
InChI	1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1;
InChIKey	AURFZBICLPNKBZ-YZRLXODZBF
ChEBI	1712
性質
化學式	C21H34O2
摩爾質量	318.49 g·mol−1
藥理學
給藥途徑	Intravenous injection
	藥代動力學：
生物半衰期	0.9–3.5 hours
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

孕烷醇酮（英語：Pregnanolone，也名為3α,5β-孕烷醇酮）也被稱為乙他諾隆（英語：eltanolone）是一種內源性的抑制性神經甾體，在體內由孕酮合成而來^[4]，和其異構體別孕烷醇酮有著類似的性質^[4]。

參考文獻

^ ^1.0 ^1.1 Carl P, Høgskilde S, Lang-Jensen T, et al. Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol Scand. October 1994, 38 (7): 734–41. PMID 7839787. doi:10.1111/j.1399-6576.1994.tb03987.x.
^ Gray HS, Holt BL, Whitaker DK, Eadsforth P. Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia. Br J Anaesth. March 1992, 68 (3): 272–6. PMID 1547051. doi:10.1093/bja/68.3.272.
^ Carl P, Høgskilde S, Nielsen JW, Sørensen MB, Lindholm M, Karlen B, Bäckstrøm T. Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. Anaesthesia. March 1990, 45 (3): 189–97. PMID 2334030. doi:10.1111/j.1365-2044.1990.tb14683.x.
^ ^4.0 ^4.1 Reddy DS. Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol. 2003, 15 (3–4): 197–234. PMID 15248811. doi:10.1615/critrevneurobiol.v15.i34.20.

孕烷醇酮

IUPAC名 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
別名	Eltanolone; 5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; 3α,5β-Tetrahydroprogesterone; 3α,5β-THP; 3α-Hydroxy-5β-tetrahydroprogesterone
識別
CAS號	128-20-1
PubChem	31402
ChemSpider	29132
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C
InChI	1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+,17-,18+,19+,20+,21-/m1/s1
InChIKey	AURFZBICLPNKBZ-YZRLXODZBF
ChEBI	1712
性質
化學式	C₂₁H₃₄O₂
摩爾質量	318.49 g·mol⁻¹
藥理學
給藥途徑	Intravenous injection^[1]
藥代動力學：
生物半衰期	0.9–3.5 hours^[1]^[2]^[3]
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。