3α-羟基类固醇脱氢酶 (B特异性)
3α-羟基类固醇脱氢酶 (B特异性)（英语：3α-hydroxysteroid dehydrogenase (B-specific)，EC 1.1.1.50（页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
| 3α-羟基类固醇脱氢酶 (B特异性) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| 识别码 | |||||||||
| EC编号 | 1.1.1.50 | ||||||||
| CAS号 | 9028-56-2 | ||||||||
| 数据库 | |||||||||
| IntEnz | IntEnz浏览 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme浏览 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代谢路径 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本体 | AmiGO / EGO | ||||||||
| |||||||||
3α-羟基类固醇脱氢酶 (B特异性)主要参与三条代谢途径：胆汁酸的生物合成、C21类固醇激素的代谢以及雄激素和雌激素的代谢。
参考文献
- JARABAK J, TALALAY P. Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases. J. Biol. Chem. 1960, 235: 2147–51. PMID 14406805.
- KOCHAKIAN CD, CARROLL BR, UHRI B. Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates. J. Biol. Chem. 1957, 224 (2): 811–8. PMID 13405910.
- Marcus PI and Talalay P. Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases. J. Biol. Chem. 1956, 218 (2): 661–674. PMID 13295221.
- Penning TM, Sharp RB. Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun. 1987, 148 (2): 646–52. PMID 3479982. doi:10.1016/0006-291X(87)90925-9.