非特异性间质性肺炎

非特异性间质性肺炎Non-specific interstitial pneumonia,简称NSIP)属于一种特发性间质性肺炎

症状

症状包含咳嗽呼吸困难,以及疲倦[1]

病因

目前认为属于一种自体免疫有关,可能为未分化型结缔组织疾病英语undifferentiated connective tissue disease的并发症[2]

分类

NSIP可依病理切片分为细胞性及纤维性两种,两种以预后不同。细胞性的镜检会显示慢性发炎但纤维化较少的情形;纤维性则会显示间质性纤维化,且发炎状态不一。在其他种类的特发性肺炎一般有一个明显的点状纤维化区域,但在NSIP中没有这种情形,一般为一整片的纤维化[3]

预后

纤维性NSIP的五年存活率约于 86% 至 92%之间,细胞性则为 100% 。大体来说NSIP的预后较寻常性间质性肺炎英语usual interstitial pneumonia(UIP)为佳[4]

参考文献

  1. ^ Cottin, Vincent, et al. "Nonspecific interstitial pneumonia: individualization of a clinicopathologic entity in a series of 12 patients." American journal of respiratory and critical care medicine 158.4 (1998): 1286-1293.
  2. ^ Kinder, Brent W., et al. "Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?." American journal of respiratory and critical care medicine 176.7 (2007): 691-697.
  3. ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project." American journal of respiratory and critical care medicine 177.12 (2008): 1338-1347.
  4. ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia." The American journal of surgical pathology 24.1 (2000): 19-33.