依美昔单抗

化合物

依美昔单抗INN:ecromeximab;开发代号:KW2871)是一种嵌合单克隆抗体,正在开发用于治疗恶性黑色素瘤[1][2]该药物被用来针对转移性黑色素瘤进行I期临床试验,[3]并在随后与高剂量的干扰素α2b联合进行了II期临床试验。[4][5]

依美昔单抗
单克隆抗体
种类完整抗体
目标GD3神经节苷脂
临床资料
ATC码
  • 未分配
识别信息
CAS号292819-64-8  ☒N
ChemSpider
  • none
UNII
化学信息
摩尔质量145255 g/mol

该药物由协和发酵工业株式会社开发。截至2015年12月,开发已停止。[6]

参考资料

  1. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Ecromeximab页面存档备份,存于互联网档案馆), American Medical Association.
  2. ^ Clinical trial number NCT00679289 for "Phase II Study of KW2871 Combined With High Dose Interferon-alpha2b in Patients With Metastatic Cutaneous Melanoma" at ClinicalTrials.gov
  3. ^ Forero, Andres; Shah, Jatin; Carlisle, Ronda; Triozzi, Pierre L.; LoBuglio, Albert F.; Wang, Wen-Quan; Fujimori, Matt; Conry, Robert M. A phase I study of an anti-GD3 monoclonal antibody, KW-2871, in patients with metastatic melanoma. Cancer Biotherapy & Radiopharmaceuticals. 2006-12, 21 (6) [2024-03-06]. ISSN 1084-9785. PMID 17257071. doi:10.1089/cbr.2006.21.561. (原始内容存档于2024-06-04). 
  4. ^ Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. [2024-03-06]. (原始内容存档于2021-04-10) (英语). 
  5. ^ Tarhini, Ahmad A.; Moschos, Stergios J.; Lin, Yan; Lin, Hui-Min; Sander, Cindy; Yin, Yan; Venhaus, Ralph; Gajewski, Thomas F.; Kirkwood, John M. Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-α2b in patients with metastatic melanoma. Melanoma Research. 2017-08, 27 (4) [2024-03-06]. ISSN 1473-5636. PMID 28489678. doi:10.1097/CMR.0000000000000353. (原始内容存档于2024-06-03). 
  6. ^ Adis insight: Ecromeximab. [2024-03-06]. (原始内容存档于2017-01-03).