肋麥角鹼
肋麥角鹼(6,8β-二甲基-10β-麥角靈)是一種有機化合物,化學式為C16H20N2,它是一種麥角靈真菌分離物。它可以N-對甲苯磺酰基-4-溴吲哚為原料,經多步反應合成、柱分離得到。[1]
肋麥角鹼 | |
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IUPAC名 6,8β-Dimethyl-10β-ergoline | |
系統名 (6aR,9R,10aS)-7,9-Dimethyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline | |
英文名 | Costaclavine |
別名 | (5R,8R,10R)-6,8-二甲基麥角靈 |
識別 | |
CAS號 | 436-41-9 ![]() |
PubChem | 160462 |
ChemSpider | 141006 |
SMILES |
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InChI |
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InChIKey | VLMZMRDOMOGGFA-RIEGTJTDBP |
性質 | |
化學式 | C16H20N2 |
摩爾質量 | 240.34 g·mol−1 |
外觀 | 白色粉末[1] |
熔點 | 180—186 °C(453—459 K)[2] 192—194 °C(465—467 K)[1] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
參考文獻
- ^ 1.0 1.1 1.2 OSANAI, Kumi; YOKOYAMA, Yuusaku; KONDO, Kazuhiro; MURAKAMI, Yasuoki. Total Synthesis of Optically Active Costaclavine. Synthetic Studies of Indoles and Related Compounds. Part 48.. Chemical and Pharmaceutical Bulletin (Pharmaceutical Society of Japan). 1999, 47 (11): 1587–1590. ISSN 0009-2363. doi:10.1248/cpb.47.1587.
- ^ Liu, Haichao; Zhang, Xiwu; Shan, Dong; Pitchakuntla, Mallesham; Ma, Yongfan; Jia, Yanxing. Total Syntheses of Festuclavine, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigaclavine G, and Dihydrosetoclavine. Organic Letters (American Chemical Society (ACS)). 2017-06-08, 19 (12): 3323–3326. ISSN 1523-7060. doi:10.1021/acs.orglett.7b01504.