1-萘基縮水甘油醚

化合物

1-萘基縮水甘油醚是一種有機化合物,化學式為C13H12O2。它可由環氧氯丙烷1-萘酚氫氧化鉀存在下反應得到。[3]它和疊氮化鈉四丁基溴化銨催化下,於乙醇水溶液中反應,可以得到1-疊氮基-3-(1-萘氧基)-2-丙醇。[4]它和1-(2-甲氧基苯基)哌嗪在乙醇中回流反應,可以得到萘哌地爾英語Naftopidil[5]

1-萘基縮水甘油醚
識別
CAS號 2461-42-9  checkY
性質
化學式 C13H12O2
摩爾質量 200.23 g·mol−1
外觀 接近無色的油狀液體[1]或淺黃色油狀液體[2]
沸點 203—203.5 °C(476.1—476.6 K)(15 mmHg)[1]
溶解性 微溶於氯仿和乙酸乙酯[2]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

  1. ^ 1.0 1.1 Ernest Robert Marle. XXXVIII.—The aryl ethers of glycide, glycerol, and glycerol-α-monochlorohydrin. J. Chem. Soc., Trans. 1912, 101 (0): 305–317 [2023-04-08]. ISSN 0368-1645. doi:10.1039/CT9120100305 (英語). 
  2. ^ 2.0 2.1 N378400 a-Naphthyl Glycidyl Ether, 90%. Toronto Research Chemicals. [2023-04-08]. (原始內容存檔於2023-04-10). 
  3. ^ Ali Gharib, Manouchehr Jahangir, Mina Roshani, Nader Noroozi Pesyan, J. (Hans) W. Scheeren, Sara Mohadesazadeh, Shirin Lagzian. Synthesis of ( S )-(-)-Propranolol by Using Cs 2.5 H 0.5 PW 12 O 40 Nanocatalyst as Green, Eco-Friendly, Reusable, and Recyclable Catalyst. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 2015-03-04, 45 (3): 350–355 [2023-04-08]. ISSN 1553-3174. doi:10.1080/15533174.2013.832323 (英語). 
  4. ^ Perumal Sarojini, Malaichamy Jeyachandran, Dharmarajan Sriram, Palraj Ranganathan, S Gandhimathi. Facile microwave-assisted synthesis and antitubercular evaluation of novel aziridine derivatives. Journal of Molecular Structure. 2021-06, 1233: 130038 [2023-04-08]. doi:10.1016/j.molstruc.2021.130038 (英語). 
  5. ^ Kanno, Takeshi; Tanaka, Akito; Shimizu, Tadashi; Nakano, Takashi; Nishizaki, Tomoyuki. Preparation of naftopidil analogs as novel anticancer agent. 2015. US20150353473.