高絲氨酸脫氫酶
高絲氨酸脫氫酶（英語：homoserine dehydrogenase，EC 1.1.1.3 （頁面存檔備份，存於網際網路檔案館））是一種以NAD+或NADP+為受體、作用於供體CH-OH基團上的氧化還原酶。這種酶能催化以下酶促反應：
| 高絲氨酸脫氫酶 | |||||||
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| 結合了NAD類似物和L-高絲氨酸的高絲氨酸脫氫酶複合物 | |||||||
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| 識別碼 | |||||||
| EC編號 | 1.1.1.3 | ||||||
| CAS號 | 9028-13-1 | ||||||
| 數據庫 | |||||||
| IntEnz | IntEnz瀏覽 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme瀏覽 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代謝路徑 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
| 基因本體 | AmiGO / EGO | ||||||
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高絲氨酸脫氫酶參與甘氨酸、絲氨酸和蘇氨酸的代謝以及賴氨酸的生物合成。高絲氨酸脫氫酶參與天冬氨酸途徑的第三步反應，在NAD或NADP的參與下將天冬氨酸半醛還原為高絲氨酸。[1][2]
參考文獻
- ^ Thomas D, Barbey R, Surdin-Kerjan Y. Evolutionary relationships between yeast and bacterial homoserine dehydrogenases. FEBS Lett. June 1993, 323 (3): 289–93. PMID 8500624. doi:10.1016/0014-5793(93)81359-8.
- ^ Cami B, Clepet C, Patte JC. Evolutionary comparisons of three enzymes of the threonine biosynthetic pathway among several microbial species. Biochimie. 1993, 75 (6): 487–95. PMID 8395899.
- BLACK S, WRIGHT NG. Homoserine dehydrogenase. J. Biol. Chem. 1955, 213 (1): 51–60. PMID 14353905.
- Starnes WL, Munk P, Maul SB, Cunningham GN, Cox DJ, Shive W. Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex. Biochemistry. 1972, 11 (5): 677–87. PMID 4551091. doi:10.1021/bi00755a003.
- Veron M, Falcoz-Kelly F, Cohen GN. The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain. Eur. J. Biochem. 1972, 28 (4): 520–7. PMID 4562990. doi:10.1111/j.1432-1033.1972.tb01939.x.