莽草酸脫氫酶

莽草酸脫氫酶(英語:shikimate dehydrogenaseEC 1.1.1.25頁面存檔備份,存於網際網路檔案館))是一種以NADP+受體、作用於供體CH-OH基團上的氧化還原酶。這種催化以下酶促反應

莽草酸脫氫酶
莽草酸脫氫酶結構
識別碼
EC編號 1.1.1.25
CAS號 9026-87-3
數據庫
IntEnz IntEnz瀏覽
BRENDA英語BRENDA BRENDA入口
ExPASy英語ExPASy NiceZyme瀏覽
KEGG KEGG入口
MetaCyc英語MetaCyc 代謝路徑
PRIAM英語PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本體 AmiGO / EGO
莽草酸 + NADP+ 3-脫氫莽草酸 + NADH + H+

上述反應中的NADP+不能以NAD+替代[1]。莽草酸脫氫酶主要參與苯丙氨酸、酪氨酸色氨酸生物合成過程——莽草酸途徑。在較高等的生物細胞中,這種酶與3-脫氫奎尼酸脫水酶一同構成一種多酶複合物[2]

功能

Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway. This pathway is found in bacteria, plants, fungi, algae, and parasites and is responsible for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) from the metabolism of carbohydrates. In contrast, animals and humans lack this pathway hence products of this biosynthetic route are essential amino acids that must be obtained through an animal's diet.

There are seven enzymes that play a role in this pathway. Shikimate dehydrogenase (also known as 3-dehydroshikimate dehydrogenase) is the fourth step of the seven step process. This step converts 3-dehydroshikimate to shikimate as well as reduces NADP+ to NADPH.

異名

由於莽草酸脫氫酶催化一個可逆的氧化還原反應,且對於莽草酸碳原子編號順序不同,所以除了它的系統名:shikimate:NADP+ 3-oxidoreductase 莽草酸:NADP+ 3-氧化還原酶之外,還存在多個異名:

  • dehydroshikimic reductase 脫氫莽草酸還原酶
  • shikimate oxidoreductase 莽草酸氧化還原酶
  • shikimate:NADP+ oxidoreductase 莽草酸:NADP+ 氧化還原酶
  • 5-dehydroshikimate reductase 5-脫氫莽草酸還原酶
  • shikimate 5-dehydrogenase 莽草酸 5-脫氫酶
  • 5-dehydroshikimic reductase 5-脫氫莽草酸還原酶
  • DHS reductase DHS還原酶
  • shikimate:NADP+ 5-oxidoreductase 莽草酸:NADP+ 5-氧化還原酶
  • AroE。

參考文獻

  1. ^ Yaniv H, Gilvarg C. Aromatic biosynthesis. XIV. 5-Dehydroshikimic reductase. J. Biol. Chem. 1955, 213 (2): 787–95. PMID 14367339. 
  2. ^ Chaudhuri S, Coggins JR. The purification of shikimate dehydrogenase from Escherichia coli. Biochem. J. 1985, 226 (1): 217–23. PMC 1144695 . PMID 3883995.