维基百科

9-羧基甲氧基甲基鸟嘌呤

9-羧基甲氧基甲基鸟嘌呤（英语：9-Carboxymethoxymethylguanine），简称CMMG，是一种化合物，被认为抗病毒药物阿昔洛韦（及其前药伐昔洛韦）的主要代谢物，并被认为是有时与这些药物相关的神经精神副作用的致病因子。这些主要由肾功能衰竭或肾功能下降的患者遭受，并且可能包括精神病性反应、幻觉和罕见的更复杂的疾病，如科塔尔综合征。 研究发现接受阿昔洛韦治疗后出现这些症状的患者的CMMG水平比正常人高得多。由于这是科塔尔综合征首次与药物副作用相关联，这一发现可能有助于科塔尔综合征的研究及其治疗。[1][2][3][4][5][6]

9-羧基甲氧基甲基鸟嘌呤
识别信息
  • 2-[(2-Amino-6-oxo-3H-purin-9-yl)methoxy]acetic acid
CAS号80685-22-9  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C8H9N5O4
摩尔质量239.19 g·mol−1
3D模型（JSmol（英语：JSmol））
  • C1=NC2=C(N1COCC(=O)O)N=C(NC2=O)N
  • InChI=1S/C8H9N5O4/c9-8-11-6-5(7(16)12-8)10-2-13(6)3-17-1-4(14)15/h2H,1,3H2,(H,14,15)(H3,9,11,12,16)
  • Key:MICNQLKUSOVNNG-UHFFFAOYSA-N

参考资料

  1. ^ Svensson JO, Barkholt L, Säwe J. Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications. March 1997, 690 (1–2): 363–6. PMID 9106067. doi:10.1016/S0378-4347(96)00424-0. 
  2. ^ Helldén A, Odar-Cederlöf I, Diener P, Barkholt L, Medin C, Svensson JO, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrology, Dialysis, Transplantation. June 2003, 18 (6): 1135–41. PMID 12748346. doi:10.1093/ndt/gfg119  . 
  3. ^ Helldén A, Odar-Cederlöf I, Larsson K, Fehrman-Ekholm I, Lindén T. Death delusion. BMJ. December 2007, 335 (7633): 1305. PMC 2151143  . PMID 18156240. doi:10.1136/bmj.39408.393137.BE. 
  4. ^ Ruiz-Roso G, Gomis A, Fernández-Lucas M, Díaz-Domínguez M, Teruel-Briones JL, Quereda C. Aciclovir and valaciclovir neurotoxicity in patients with renal failure. Nefrologia. 2012, 32 (1): 114–5. PMID 22294022. doi:10.3265/Nefrologia.pre2011.Nov.11247. 
  5. ^ Lindén, T.; Helldén, A. Cotard's syndrome as an adverse effect of acyclovir treatment in renal failure. Journal of the Neurological Sciences. 2013, 333: e650. S2CID 54428588. doi:10.1016/j.jns.2013.07.2255. 
  6. ^ Saul H. Reversing walking corpse syndrome: Cotard's Syndrome trigger found - and it's a household cold sore cream.. The Independent. 18 October 2013 [2023-04-20]. （原始内容存档于2015-09-25）. 
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