2-丁基咪唑

2-丁基咪唑
英文名	2-butylimidazole
别名	2-正丁基咪唑
识别
CAS号	50790-93-7
PubChem	11815351
性质
化学式	C7H12N2
摩尔质量	124.18 g·mol−1
外观	晶体粉末
密度	0.979±0.06 g·cm−3（20 °C）
熔点	52 °C
沸点	294 °C
溶解性（水）	2 g（25 °C）
pKa	14.42±0.10（25 °C）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

2-丁基咪唑是一种有机化合物，化学式为C₇H₁₂N₂。它可由1-(二乙氧基甲基)咪唑的锂盐和1-碘丁烷反应得到，产物分别用盐酸、碳酸氢钠处理后用三氯甲烷萃取提纯。^[3]2-丁基-4,5-二氢咪唑的氧化反应也能得到2-丁基咪唑。^[4]它和碘在碳酸钠的存在下于二氧六环中反应，可以得到2-丁基-4,5-二碘咪唑。^[5]它可以和锌形成金属有机框架材料。^[6]

参考文献

^ ^1.0 ^1.1 ^1.2 2-Butylimidazole 97.0+%, TCI America(TM). fisher scientific. [2021-09-15]. （原始内容存档于2021-09-15）.
^ ^2.0 ^2.1 ^2.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-09-15].
^ N. J. Curtis, R. S. Brown. An easily introduced and removed protecting group for imidazole nitrogen: a convenient route to 2-substituted imidazoles. The Journal of Organic Chemistry. 1980-09, 45 (20): 4038–4040 [2021-09-15]. ISSN 0022-3263. doi:10.1021/jo01308a019. （原始内容存档于2021-09-15）（英语）.
^ Mohammad Abdollahi-Alibeik, Iraj Mohammadpoor-Baltork, Mohammad Ali Zolfigol. Alumina supported potassium permanganate: an efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions. Bioorganic & Medicinal Chemistry Letters. 2004-12, 14 (24): 6079–6082 [2021-09-15]. doi:10.1016/j.bmcl.2004.09.070 （英语）.
^ Steven J. Wittenberger, Andrew Tasker, Bryan K. Sorensen, B. Gregory Donner. 2-Butyl-4-iodoimidazole-5-carboxaldehyde: A Versatile Intermediate for the Synthesis of Highly Functionalized Imidazoles. Synthetic Communications. 1993-12, 23 (22): 3231–3248 [2021-09-15]. ISSN 0039-7911. doi:10.1080/00397919308011184 （英语）.
^ Hatem M. Titi, Mihails Arhangelskis, Athanassios D. Katsenis, Cristina Mottillo, Ghada Ayoub, Jean-Louis Do, Athena M. Fidelli, Robin D. Rogers, Tomislav Friščić. Metal–Organic Frameworks as Fuels for Advanced Applications: Evaluating and Modifying the Combustion Energy of Popular MOFs. Chemistry of Materials. 2019-07-09, 31 (13): 4882–4888 [2021-09-15]. ISSN 0897-4756. doi:10.1021/acs.chemmater.9b01488. （原始内容存档于2022-01-06）（英语）.

[fish-1] 1.0 ^1.1 ^1.2 2-Butylimidazole 97.0+%, TCI America(TM). fisher scientific. [2021-09-15]. （原始内容存档于2021-09-15）.

[ACD-2] 2.0 ^2.1 ^2.2 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 ((C) 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-09-15].

[curtis-3] N. J. Curtis, R. S. Brown. An easily introduced and removed protecting group for imidazole nitrogen: a convenient route to 2-substituted imidazoles. The Journal of Organic Chemistry. 1980-09, 45 (20): 4038–4040 [2021-09-15]. ISSN 0022-3263. doi:10.1021/jo01308a019. （原始内容存档于2021-09-15）（英语）.

[4] Mohammad Abdollahi-Alibeik, Iraj Mohammadpoor-Baltork, Mohammad Ali Zolfigol. Alumina supported potassium permanganate: an efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions. Bioorganic & Medicinal Chemistry Letters. 2004-12, 14 (24): 6079–6082 [2021-09-15]. doi:10.1016/j.bmcl.2004.09.070 （英语）.

[5] Steven J. Wittenberger, Andrew Tasker, Bryan K. Sorensen, B. Gregory Donner. 2-Butyl-4-iodoimidazole-5-carboxaldehyde: A Versatile Intermediate for the Synthesis of Highly Functionalized Imidazoles. Synthetic Communications. 1993-12, 23 (22): 3231–3248 [2021-09-15]. ISSN 0039-7911. doi:10.1080/00397919308011184 （英语）.

[6] Hatem M. Titi, Mihails Arhangelskis, Athanassios D. Katsenis, Cristina Mottillo, Ghada Ayoub, Jean-Louis Do, Athena M. Fidelli, Robin D. Rogers, Tomislav Friščić. Metal–Organic Frameworks as Fuels for Advanced Applications: Evaluating and Modifying the Combustion Energy of Popular MOFs. Chemistry of Materials. 2019-07-09, 31 (13): 4882–4888 [2021-09-15]. ISSN 0897-4756. doi:10.1021/acs.chemmater.9b01488. （原始内容存档于2022-01-06）（英语）.

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