促卵泡激素β亚基

Follicle stimulating hormone, beta polypeptide
促卵泡激素，β多肽
Follicle stimulating hormone, beta polypeptide; 促卵泡激素，β多肽
	PDB rendering based on 1fl7.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1FL7, 1XWD, 4AY9
标识
代号	FSHB
扩展标识	遗传学：136530 鼠基因：95582 同源基因：430 GeneCards: FSHB Gene
基因本体论描述
分子功能	· hormone activity; · protein binding; · follicle-stimulating hormone activity; · protein heterodimerization activity;
细胞成分	· extracellular region; · cytoplasm;
生物过程	· ovarian follicle development; · progesterone biosynthetic process; · signal transduction; · transforming growth factor beta receptor signaling pathway; · spermatogenesis; · female gamete generation; · female pregnancy; · positive regulation of cell proliferation; · peptide hormone processing; · positive regulation of cell migration; · cellular protein metabolic process; · positive regulation of transcription from RNA polymerase II promoter; · Sertoli cell proliferation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	2488
Ensembl	ENSG00000131808
UniProt	P01225
mRNA序列	NM_000510
蛋白序列	NP_000501
基因位置	Chr 11:; 30.25 – 30.26 Mb
PubMed查询	[1]
	查; 论; 编;

促卵泡激素β亚基（英语：Follitropin subunit beta 或 follicle-stimulating hormone beta subunit 缩写FSH-B）是一种由人类基因FSHB 编码的蛋白质^[1]^[2]^[3] 。其RNA的选择性剪接可形成该蛋白的两种蛋白异型体。

功能

垂体糖蛋白激素家族包括促卵泡激素、黄体生成素、人绒毛膜促性腺激素和促甲状腺激素，所有这些糖蛋白激素都包括一个共同的α亚基和一个特异的β亚基。FSHB 基因编码的就是促卵泡激素的β亚基。 In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.^[3]

参考文献

^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. PMID 2885163. doi:10.1089/dna.1987.6.205.
^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. PMID 3151250. doi:10.1007/BF01024882.
^ ^3.0 ^3.1 Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide. （原始内容存档于2009-05-11）.

延伸阅读

Barrios-De-Tomasi J; Timossi C; Merchant H; et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. Mol. Cell. Endocrinol. 2002, 186 (2): 189–98. PMID 11900895. doi:10.1016/S0303-7207(01)00657-8.
Saxena BB, Rathnam P. Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J. Biol. Chem. 1976, 251 (4): 993–1005. PMID 1249074.
Keene JL; Matzuk MM; Otani T; et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem. 1989, 264 (9): 4769–75. PMID 2494176.
Jameson JL, Becker CB, Lindell CM, Habener JF. Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol. Endocrinol. 1988, 2 (9): 806–15. PMID 3139991. doi:10.1210/mend-2-9-806.
Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J. Clin. Endocrinol. Metab. 1974, 39 (1): 203–5. PMID 4835136. doi:10.1210/jcem-39-1-203.
Fujiki Y, Rathnam P, Saxena BB. Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochim. Biophys. Acta. 1980, 624 (2): 428–35. PMID 6774759.
Böckers TM, Nieschlag E, Kreutz MR, Bergmann M. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res. 1995, 278 (3): 595–600. PMID 7850869. doi:10.1007/BF00331379.
Matthews CH; Borgato S; Beck-Peccoz P; et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet. 1993, 5 (1): 83–6. PMID 8220432. doi:10.1038/ng0993-83.
Layman LC; Lee EJ; Peak DB; et al. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. N. Engl. J. Med. 1997, 337 (9): 607–11. PMID 9271483. doi:10.1056/NEJM199708283370905.
Cargill M; Altshuler D; Ireland J; et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 1999, 22 (3): 231–8. PMID 10391209. doi:10.1038/10290.
Grasso P, Rozhavskaya-Arena M, Reichert LE. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul. Pept. 1999, 81 (1–3): 67–71. PMID 10395410. doi:10.1016/S0167-0115(99)00022-1.
Ben-Menahem D; Hyde R; Pixley M; et al. Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. Biochemistry. 1999, 38 (46): 15070–7. PMID 10563789. doi:10.1021/bi991510c.
Dias Neto E; Correa RG; Verjovski-Almeida S; et al. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (7): 3491–6. PMC 16267  . PMID 10737800. doi:10.1073/pnas.97.7.3491.
Hartley JL, Temple GF, Brasch MA. DNA Cloning Using In Vitro Site-Specific Recombination. Genome Res. 2001, 10 (11): 1788–95. PMC 310948  . PMID 11076863. doi:10.1101/gr.143000.
Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol. 2001, 15 (3): 378–89. PMID 11222739. doi:10.1210/me.15.3.378.
Amoresano A; Orrù S; Siciliano RA; et al. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. Biol. Chem. 2002, 382 (6): 961–8. PMID 11501762. doi:10.1515/BC.2001.120.
Walton WJ; Nguyen VT; Butnev VY; et al. Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. J. Clin. Endocrinol. Metab. 2001, 86 (8): 3675–85. PMID 11502795. doi:10.1210/jc.86.8.3675.

[pmid2885163-1] Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. PMID 2885163. doi:10.1089/dna.1987.6.205.

[pmid3151250-2] Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. PMID 3151250. doi:10.1007/BF01024882.

[entrez-3] 3.0 ^3.1 Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide. （原始内容存档于2009-05-11）.

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