CRADD

位於12號人類染色體的基因

含有死亡结构域的蛋白质CRADD(英语:Death domain-containing protein CRADD)是人类中由CRADD基因编码的蛋白质[6][7][8]

CRADD
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名CRADD;, MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
外部IDOMIM603454 MGI1336168 HomoloGene2821 GeneCardsCRADD
相关疾病
阿尔茨海默病、​syndromic intellectual disability[1]
基因位置(人类
12号染色体
染色体12号染色体[2]
12号染色体
CRADD的基因位置
CRADD的基因位置
基因座12q22起始93,677,375 bp[2]
终止93,894,840 bp[2]
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_003805
​NM_001320099
​NM_001320100
​NM_001320101
​NM_001330126

NM_009950
​NM_001330138
​NM_001330141
​NM_001330175

蛋白序列

NP_001317067
​NP_001317070
​NP_001317104
​NP_034080

基因位置​(UCSC)Chr 12: 93.68 – 93.89 MbChr 10: 95.01 – 95.16 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

功能

该基因编码的蛋白质是含有死亡结构域(CARD/DD)的蛋白质,已被证明可诱导细胞凋亡。通过其CARD结构域英语CARD (domain),该蛋白与胱天蛋白酶2/ICH1相互作用,从而将胱天蛋白酶2/ICH1募集到细胞死亡信号转导复合物中,该复合物包括肿瘤坏死因子受体1英语Tumor necrosis factor receptor 1(TNFR1A)、RIPK1英语RIPK1/RIP激酶和许多其他含有CARD结构域的蛋白。[8]

相互作用

CRADD已被证明与RIPK1英语RIPK1[6][7]胱天蛋白酶2[6][9][10]相互作用。

参考资料

  1. ^ 與CRADD相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000169372 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000045867 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ 6.0 6.1 6.2 Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule (PDF). Nature. January 1997, 385 (6611): 86–9. Bibcode:1997Natur.385...86D. PMID 8985253. S2CID 4317538. doi:10.1038/385086a0. hdl:2027.42/62739 . 
  7. ^ 7.0 7.1 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. March 1997, 57 (4): 615–9. PMID 9044836. 
  8. ^ 8.0 8.1 Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain. [2024-01-20]. (原始内容存档于2010-12-05). 
  9. ^ Tinel A, Tschopp J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. May 2004, 304 (5672): 843–6. Bibcode:2004Sci...304..843T. PMID 15073321. S2CID 6583298. doi:10.1126/science.1095432. 
  10. ^ Droin N, Beauchemin M, Solary E, Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. December 2000, 60 (24): 7039–47. PMID 11156409. 

外部链接

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