阿拉普利

阿拉普利
临床资料
AHFS/Drugs.com	国际药品名称
给药途径	口服
ATC码	未分配;
法律规范状态
法律规范	处方药（℞-only）;
识别信息
	IUPAC命名法 (2S)-2-[[(2S)-1-[(2S)-3-acetylsulfanyl-2-methylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid; ;
CAS号	74258-86-9
PubChem CID	71992;
ChemSpider	64993 ;
UNII	X39TL7JDPF;
KEGG	D01900 ;
ChEMBL	ChEMBL2103775 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID3048576 ;
化学信息
化学式	C20H26N2O5S
摩尔质量	406.50 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C[C@H](CSC(=O)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O;
	InChI InChI=1S/C20H26N2O5S/c1-13(12-28-14(2)23)19(25)22-10-6-9-17(22)18(24)21-16(20(26)27)11-15-7-4-3-5-8-15/h3-5,7-8,13,16-17H,6,9-12H2,1-2H3,(H,21,24)(H,26,27)/t13-,16+,17+/m1/s1 ; Key:FHHHOYXPRDYHEZ-COXVUDFISA-N ;

阿拉普利（INN：alacepril）是一种ACE抑制剂药物，可用于治疗高血压。该药物代谢为卡托普利和去乙酰阿拉普利。^[1]阿拉普利主要用于治疗高血压，在某些情况下用于治疗肾血管性高血压。它通常与其他药物结合使用，特别是其他降血压药物，如噻嗪类利尿剂，以最大限度地发挥其功效。^[2]

作用机制

在体内，当阿拉普利经历脱乙酰化时，它会失去类似于苯丙氨酸的分子，从而将其转化为卡托普利。^[3]卡托普利通过两种方式发挥降血压作用。首先，它抑制血管紧张素1（一种前体分子）转化为血管紧张素II（一种使血管变窄的血管收缩剂）的过程。其次，卡托普利可以防止缓激肽的分解，缓激肽是一种自然松弛血管的血管舒张肽。^[4]

参考资料

^ Alacepril. IBM Micromedex. 24 August 2010 [23 June 2022].
^ Alacepril. DrugCentral online drug compendium. [13 April 2024]. It is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It used for the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics).
^ Campese VM, Lakdawala RS. The Challenges of Blood Pressure Control in Dialysis Patients. Nissenson AR, Fine RN (编). Handbook of dialysis therapy 5th. Philadelphia, PA: Elsevier. 2017. ISBN 978-0-323-39154-2. doi:10.1016/B978-0-323-39154-2.00053-9. The sulfhydryl agents, such as alacepril, delapril, and moveltopril, are prodrugs and thus are converted to captopril in vivo. These sulfhydryl-containing compounds have a slower onset and longer duration of action than captopril.
^ Odaka C, Mizuochi T. Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals. Clinical and Experimental Immunology. September 2000, 121 (3): 515–522. PMC 1905724  . PMID 10971519. doi:10.1046/j.1365-2249.2000.01323.x.

外部链接

维基共享资源上的相关多媒体资源：阿拉普利

[1] Alacepril. IBM Micromedex. 24 August 2010 [23 June 2022].

[2] Alacepril. DrugCentral online drug compendium. [13 April 2024]. It is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It used for the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics).

[3] Campese VM, Lakdawala RS. The Challenges of Blood Pressure Control in Dialysis Patients. Nissenson AR, Fine RN (编). Handbook of dialysis therapy 5th. Philadelphia, PA: Elsevier. 2017. ISBN 978-0-323-39154-2. doi:10.1016/B978-0-323-39154-2.00053-9. The sulfhydryl agents, such as alacepril, delapril, and moveltopril, are prodrugs and thus are converted to captopril in vivo. These sulfhydryl-containing compounds have a slower onset and longer duration of action than captopril.

[4] Odaka C, Mizuochi T. Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals. Clinical and Experimental Immunology. September 2000, 121 (3): 515–522. PMC 1905724  . PMID 10971519. doi:10.1046/j.1365-2249.2000.01323.x.

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