二肽基肽酶-4

Dipeptidyl-peptidase 4
Dipeptidyl-peptidase 4
	人类DPP-4的带状结构图; 来自PDB 1PFQ.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4J3J, 4JH0, 4KR0, 4L72, 4LKO, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV
标识
代号	DPP4; ADABP; ADCP2; CD26; DPPIV; TP103
扩展标识	遗传学：102720 鼠基因：94919 同源基因：3279 ChEMBL: 284 GeneCards: DPP4 Gene
EC编号	3.4.14.5
基因本体论描述
分子功能	· virus receptor activity; · protease binding; · serine-type endopeptidase activity; · receptor binding; · protein binding; · serine-type peptidase activity; · dipeptidyl-peptidase activity; · identical protein binding; · protein homodimerization activity;
细胞成分	· lysosomal membrane; · plasma membrane; · focal adhesion; · cell surface; · membrane; · integral component of membrane; · apical plasma membrane; · lamellipodium; · endocytic vesicle; · lamellipodium membrane; · membrane raft; · intercellular canaliculus; · extracellular exosome; · invadopodium membrane;
生物过程	· behavioral fear response; · response to hypoxia; · proteolysis; · positive regulation of cell proliferation; · negative regulation of extracellular matrix disassembly; · T cell costimulation; · regulation of cell-cell adhesion mediated by integrin; · locomotory exploration behavior; · psychomotor behavior; · T cell activation; · endothelial cell migration; · viral entry into host cell;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	1803
Ensembl	ENSG00000197635
UniProt	P27487
mRNA序列	NM_001935
蛋白序列	NP_001926
基因位置	Chr 2:; 161.99 – 162.07 Mb
PubMed查询	[1]
	查; 论; 编;

二肽基肽酶-4（dipeptidyl peptidase-4，DPP-4）又称T细胞表面抗原CD26，是一种跨膜丝氨酸多肽酶，分布广泛，作用多向^[1]。可作为二肽酶水解多肽，从而调节肽类激素、神经肽、细胞因子和生长因子的活性，另可作为表面抗原与其他分子或蛋白共同合作，介导细胞与基质、细胞与细胞之间的相互作用。在免疫激活、炎症反应和肿瘤发生中起到各种调节作用^[2]。

二肽基肽酶-4由DPPP4基因编码^[3]。DPP4与ATRN、FAP、DPP8和DPP9有关联^[4]。

延伸阅读

Ansorge, S.; Bühling, F.; Kähne, T.; Lendeckel, U.; Reinhold, D.; Täger, M.; Wrenger, S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in Experimental Medicine and Biology. 1997, 421: 127–140 [2021-11-10]. ISSN 0065-2598. PMID 9330689. doi:10.1007/978-1-4757-9613-1_17. （原始内容存档于2021-11-10）. （页面存档备份，存于互联网档案馆）
Reinhold, Dirk; Kähne, Thilo; Steinbrecher, Andreas; Wrenger, Sabine; Neubert, Klaus; Ansorge, Siegfried; Brocke, Stefan. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 2002-07, 383 (7-8): 1133–1138 [2021-11-10]. ISSN 1431-6730. PMID 12437097. doi:10.1515/BC.2002.123. （原始内容存档于2022-04-10）. （页面存档备份，存于互联网档案馆）
Sato, Kazuya; Dang, Nam H. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). International Journal of Oncology. 2003-03, 22 (3): 481–497 [2021-11-10]. ISSN 1019-6439. PMID 12579300. （原始内容存档于2021-11-10）. （页面存档备份，存于互联网档案馆）
De Meester, Ingrid; Lambeir, Anne-Marie; Proost, Paul; Scharpé, Simon. Dipeptidyl Peptidase IV Substrates. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease 524. Boston, MA: Springer US. 2004: 3–17. ISBN 978-0-306-47717-1. PMID 12675218. doi:10.1007/0-306-47920-6_1.
Koch, Sina; Anthonsen, Dorit; Skovbjerg, Hanne; Sjöström, Hans. On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease 524. Boston: Kluwer Academic Publishers. 2004: 181–187. ISBN 978-0-306-47717-1. PMID 12675238. doi:10.1007/0-306-47920-6_22 （英语）.
Pro, B.; Dang, N. H. CD26/dipeptidyl peptidase IV and its role in cancer. Histology and Histopathology. 2004-10, 19 (4): 1345–1351 [2021-11-10]. ISSN 0213-3911. PMID 15375776. doi:10.14670/HH-19.1345. （原始内容存档于2022-01-20）. （页面存档备份，存于互联网档案馆）

参考文献

^ 王欣,李游,桂辛蕊,程先超. 二肽基肽酶-4及其抑制剂的研究进展[J]. 中国药学杂志, 2013, 48(21): 1789-1796 https://doi.org/10.11669/cpj.2013.21.003
^ 李娟,赵维纲. 糖脂代谢相关疾病专题二肽基肽酶-Ⅳ—血糖控制之外的作用[J]. 中华临床营养杂志,2015,23:(4)：244-249.DOI:10.3760/cma.j.issn.1674-635X.2015.04.011
^ Kameoka, Junichi; Tanaka, Toshiaki; Nojima, Yoshihisa; Schlossman, Stuart F.; Morimoto, Chikao. Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26. Science. 1993-07-23, 261 (5120): 466–469 [2021-11-10]. ISSN 0036-8075. PMID 8101391. doi:10.1126/science.8101391. （原始内容存档于2021-11-10）（英语）. （页面存档备份，存于互联网档案馆）
^ Lisa AK. Mitra Assemi Betsy AC. Diabetes Mellitus. In: Koda-Kimble Mary Anne et al. Applied Therapeutics: The Clinical Use Of Drugs, 9th ed. 2009, Chap. 50.

外部链接

The MEROPS online database for peptidases and their inhibitors: S09.003^{[失效链接]}
医学主题词表（MeSH）：Dipeptidyl-Peptidase+IV
Banting and Best Diabetes Centre at UT dpp4

这是一篇与生物化学相关的小作品。您可以通过编辑或修订扩充其内容。

[1] 王欣,李游,桂辛蕊,程先超. 二肽基肽酶-4及其抑制剂的研究进展[J]. 中国药学杂志, 2013, 48(21): 1789-1796 https://doi.org/10.11669/cpj.2013.21.003

[2] 李娟,赵维纲. 糖脂代谢相关疾病专题二肽基肽酶-Ⅳ—血糖控制之外的作用[J]. 中华临床营养杂志,2015,23:(4)：244-249.DOI:10.3760/cma.j.issn.1674-635X.2015.04.011

[pmid8101391-3] Kameoka, Junichi; Tanaka, Toshiaki; Nojima, Yoshihisa; Schlossman, Stuart F.; Morimoto, Chikao. Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26. Science. 1993-07-23, 261 (5120): 466–469 [2021-11-10]. ISSN 0036-8075. PMID 8101391. doi:10.1126/science.8101391. （原始内容存档于2021-11-10）（英语）. （页面存档备份，存于互联网档案馆）

[4] Lisa AK. Mitra Assemi Betsy AC. Diabetes Mellitus. In: Koda-Kimble Mary Anne et al. Applied Therapeutics: The Clinical Use Of Drugs, 9th ed. 2009, Chap. 50.

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