丁吡考胺

化合物

丁吡考胺(英语:Bupicomide,化学名:5-丁基吡啶-2-酰胺,5-Butylpyridine-2-carboxamide)是一种有机化合物,化学式C10H12N2O,具有β受体阻滞剂功能,在临床上用于血管舒张[2][3][4]

丁吡考胺
IUPAC名
5-Butylpyridine-2-carboxamide
别名 Sch-10595; Fusaramide[1]
识别
CAS号 22632-06-0  checkY
PubChem 31447
ChemSpider 29167
SMILES
 
  • O=C(c1ncc(cc1)CCCC)N
InChI
 
  • 1/C10H14N2O/c1-2-3-4-8-5-6-9(10(11)13)12-7-8/h5-7H,2-4H2,1H3,(H2,11,13)
InChIKey VKSPIPWLHGKJQO-UHFFFAOYAT
性质
化学式 C10H14N2O
摩尔质量 178.23 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Bupicomide页面存档备份,存于互联网档案馆), Chemical Book
  2. ^ Chrysant, SG; Adamopoulos, P; Tsuchiya, M; Frohlich, ED. Systemic and renal hemodynamic effects of bupicomide: A new vasodilator. American Heart Journal. 1976, 92 (3): 335–9. PMID 782220. doi:10.1016/s0002-8703(76)80114-7. 
  3. ^ Velasco, M; Gilbert, CA; Rutledge, CO; McNay, JL. Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine. Clinical Pharmacology and Therapeutics. 1975, 18 (2): 145–53. PMID 1097150. S2CID 19966617. doi:10.1002/cpt1975182145. 
  4. ^ Velasco, M.; McNay, J. L. Physiologic mechanisms of bupicomide- and hydralazine-induced increase in plasma renin activity in hypertensive patients.. Mayo Clinic Proceedings. 1977, 52 (7): 430–2. PMID 875465. 

外部链接

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