1-萘基缩水甘油醚

化合物

1-萘基缩水甘油醚是一种有机化合物,化学式为C13H12O2。它可由环氧氯丙烷1-萘酚氢氧化钾存在下反应得到。[3]它和叠氮化钠四丁基溴化铵催化下,于乙醇水溶液中反应,可以得到1-叠氮基-3-(1-萘氧基)-2-丙醇。[4]它和1-(2-甲氧基苯基)哌嗪在乙醇中回流反应,可以得到萘哌地尔英语Naftopidil[5]

1-萘基缩水甘油醚
识别
CAS号 2461-42-9  checkY
性质
化学式 C13H12O2
摩尔质量 200.23 g·mol−1
外观 接近无色的油状液体[1]或浅黄色油状液体[2]
沸点 203—203.5 °C(476.1—476.6 K)(15 mmHg)[1]
溶解性 微溶于氯仿和乙酸乙酯[2]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 Ernest Robert Marle. XXXVIII.—The aryl ethers of glycide, glycerol, and glycerol-α-monochlorohydrin. J. Chem. Soc., Trans. 1912, 101 (0): 305–317 [2023-04-08]. ISSN 0368-1645. doi:10.1039/CT9120100305 (英语). 
  2. ^ 2.0 2.1 N378400 a-Naphthyl Glycidyl Ether, 90%. Toronto Research Chemicals. [2023-04-08]. (原始内容存档于2023-04-10). 
  3. ^ Ali Gharib, Manouchehr Jahangir, Mina Roshani, Nader Noroozi Pesyan, J. (Hans) W. Scheeren, Sara Mohadesazadeh, Shirin Lagzian. Synthesis of ( S )-(-)-Propranolol by Using Cs 2.5 H 0.5 PW 12 O 40 Nanocatalyst as Green, Eco-Friendly, Reusable, and Recyclable Catalyst. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry. 2015-03-04, 45 (3): 350–355 [2023-04-08]. ISSN 1553-3174. doi:10.1080/15533174.2013.832323 (英语). 
  4. ^ Perumal Sarojini, Malaichamy Jeyachandran, Dharmarajan Sriram, Palraj Ranganathan, S Gandhimathi. Facile microwave-assisted synthesis and antitubercular evaluation of novel aziridine derivatives. Journal of Molecular Structure. 2021-06, 1233: 130038 [2023-04-08]. doi:10.1016/j.molstruc.2021.130038 (英语). 
  5. ^ Kanno, Takeshi; Tanaka, Akito; Shimizu, Tadashi; Nakano, Takashi; Nishizaki, Tomoyuki. Preparation of naftopidil analogs as novel anticancer agent. 2015. US20150353473.