白细胞介素-7

白细胞介素-7
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3DI2、3DI3
識別號
别名	IL7；, IL-7, interleukin 7
外部ID	OMIM：146660 MGI：96561 HomoloGene：680 GeneCards：IL7
基因位置（人类）
染色体	8號染色體
终止	78,805,523 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	7,678,820 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • interleukin-7 receptor binding; • 生長因子活性; • 細胞因子受體結合; • 細胞因子活性;
細胞組分	• 細胞外空間; • 細胞外區域; • collagen-containing extracellular matrix;
生物學過程	• negative regulation of catalytic activity; • cell-cell signaling; • negative regulation of extrinsic apoptotic signaling pathway; • positive regulation of organ growth; • negative regulation of apoptotic process; • 骨质吸收; • humoral immune response; • 免疫反应; • positive regulation of cell population proliferation; • animal organ morphogenesis; • 基因調節; • homeostasis of number of cells within a tissue; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • T cell lineage commitment; • positive regulation of B cell proliferation; • positive regulation of T cell differentiation; • interleukin-7-mediated signaling pathway; • regulation of signaling receptor activity; • positive regulation of cytokine-mediated signaling pathway; • cytokine-mediated signaling pathway; • positive regulation of chemokine production; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of gene expression; • positive regulation of B cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	3574
	16196
	ENSG00000104432
	ENSMUSG00000040329
	P13232
	P10168
	NM_000880; NM_001199886; NM_001199887; NM_001199888
	NM_008371; NM_001313888; NM_001313889; NM_001313890
	NP_000871; NP_001186815; NP_001186816; NP_001186817
	NP_001300817; NP_001300818; NP_001300819; NP_032397
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白细胞介素-7（英語：Interleukin 7，缩写IL-7）是一种由人类基因 IL7 编码的蛋白质^[5]，主要由骨髓和胸腺中的基质细胞分泌^[6]^[7]^[8]，角质形成细胞^[9]、樹突狀細胞^[10]、肝細胞^[11]、神經元、上皮組織^[12]也会产生该因子，但正常淋巴细胞不会产生该因子^[13]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000104432 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000040329 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. June 1988, 333 (6173): 571–3. Bibcode:1988Natur.333..571N. PMID 3259677. S2CID 4315541. doi:10.1038/333571a0.
^ Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. U.S.A. January 1989, 86 (1): 302–6. Bibcode:1989PNAS...86..302G. PMC 286452  . PMID 2643102. doi:10.1073/pnas.86.1.302  .
^ Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA. The gene for human interleukin 7 (IL7) is at 8q12-13. Hum. Genet. July 1989, 82 (4): 371–2. PMID 2786840. S2CID 30870920. doi:10.1007/BF00274000.
^ Lupton SD, Gimpel S, Jerzy R, et al. Characterization of the human and murine IL-7 genes. J. Immunol. 1990, 144 (9): 3592–601. PMID 2329282. S2CID 36007598. doi:10.4049/jimmunol.144.9.3592  .
^ Heufler C, Topar G, Grasseger A, et al. Interleukin 7 is produced by murine and human keratinocytes. J. Exp. Med. September 1993, 178 (3): 1109–14. PMC 2191157  . PMID 8350050. doi:10.1084/jem.178.3.1109.
^ Kröncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur. J. Immunol. October 1996, 26 (10): 2541–4. PMID 8898972. S2CID 20992591. doi:10.1002/eji.1830261040.
^ Sawa Y, Arima Y, Ogura H, et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity. March 2009, 30 (3): 447–57. PMID 19285437. doi:10.1016/j.immuni.2009.01.007  .
^ Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 1995, 95 (6): 2945–53. PMC 295983  . PMID 7769137. doi:10.1172/JCI118002.
^ Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. June 2002, 99 (11): 3892–904. PMID 12010786. doi:10.1182/blood.V99.11.3892  .

外部链接

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000104432 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000040329 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3259677-5] Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. June 1988, 333 (6173): 571–3. Bibcode:1988Natur.333..571N. PMID 3259677. S2CID 4315541. doi:10.1038/333571a0.

[pmid2643102-6] Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE. Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc. Natl. Acad. Sci. U.S.A. January 1989, 86 (1): 302–6. Bibcode:1989PNAS...86..302G. PMC 286452  . PMID 2643102. doi:10.1073/pnas.86.1.302  .

[pmid2786840-7] Sutherland GR, Baker E, Fernandez KE, Callen DF, Goodwin RG, Lupton S, Namen AE, Shannon MF, Vadas MA. The gene for human interleukin 7 (IL7) is at 8q12-13. Hum. Genet. July 1989, 82 (4): 371–2. PMID 2786840. S2CID 30870920. doi:10.1007/BF00274000.

[8] Lupton SD, Gimpel S, Jerzy R, et al. Characterization of the human and murine IL-7 genes. J. Immunol. 1990, 144 (9): 3592–601. PMID 2329282. S2CID 36007598. doi:10.4049/jimmunol.144.9.3592  .

[9] Heufler C, Topar G, Grasseger A, et al. Interleukin 7 is produced by murine and human keratinocytes. J. Exp. Med. September 1993, 178 (3): 1109–14. PMC 2191157  . PMID 8350050. doi:10.1084/jem.178.3.1109.

[10] Kröncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur. J. Immunol. October 1996, 26 (10): 2541–4. PMID 8898972. S2CID 20992591. doi:10.1002/eji.1830261040.

[11] Sawa Y, Arima Y, Ogura H, et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity. March 2009, 30 (3): 447–57. PMID 19285437. doi:10.1016/j.immuni.2009.01.007  .

[12] Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 1995, 95 (6): 2945–53. PMC 295983  . PMID 7769137. doi:10.1172/JCI118002.

[Fry_TJ,_Mackall_CL_2002_3892–904-13] Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. June 2002, 99 (11): 3892–904. PMID 12010786. doi:10.1182/blood.V99.11.3892  .

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