硫酸-4-乙基苯酯

硫酸-4-乙基苯酯
别名	O-(4-乙基苯基)硫酸
识别
CAS号	85734-98-1
PubChem	20822574
性质
化学式	C8H10O4S
摩尔质量	202.23 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

硫酸-4-乙基苯酯是一种单硫酸酯，化学式为C₈H₁₀O₄S。它可由4-乙基苯酚和三甲胺三氧化硫或氯磺酸反应制得。^[1]^[2]

它是肠道细菌产生的代谢物，大量存在时有毒。这种代谢物水平升高与一些疾病有关，包括慢性肾病和自闭症。^[3]^[4]^[5]^[6]^[7]

参考文献

^ Mário S.P. Correia, Caroline Ballet, Hannes Meistermann, Louis P. Conway, Daniel Globisch. Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry. Bioorganic & Medicinal Chemistry. 2019-03, 27 (6): 955–962 [2022-03-05]. doi:10.1016/j.bmc.2019.01.031. （原始内容存档于2020-02-13）（英语）.
^ Grimes, A. J. Synthesis of S35-labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-tyrosine O-sulfate. Biochemical Journal, 1959. 73: 732-739. ISSN 0264-6021.
^ Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T. Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS. Mass Spectrometry: S0017. PMID 24349936. doi:10.5702/massspectrometry.S0017.
^ Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. Journal of Oral Biology. PMID 27390783. doi:10.13188/2377-987X.1000020.
^ Virdee MS, Saini N, Kay CD, Neilson AP, Kwan ST, Helfrich KK, et al. An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder. Scientific Reports. January 2021, 11 (1): 248. PMID 33420159. doi:10.1038/s41598-020-80093-8.
^ Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD. The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience: 738220. PMID 34744609. doi:10.3389/fnins.2021.738220.
^ Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, et al. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature. February 2022, 602 (7898): 647–653. PMID 35165440. doi:10.1038/s41586-022-04396-8.

[1] Mário S.P. Correia, Caroline Ballet, Hannes Meistermann, Louis P. Conway, Daniel Globisch. Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry. Bioorganic & Medicinal Chemistry. 2019-03, 27 (6): 955–962 [2022-03-05]. doi:10.1016/j.bmc.2019.01.031. （原始内容存档于2020-02-13）（英语）.

[2] Grimes, A. J. Synthesis of S35-labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-tyrosine O-sulfate. Biochemical Journal, 1959. 73: 732-739. ISSN 0264-6021.

[3] Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T. Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS. Mass Spectrometry: S0017. PMID 24349936. doi:10.5702/massspectrometry.S0017.

[4] Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. Journal of Oral Biology. PMID 27390783. doi:10.13188/2377-987X.1000020.

[5] Virdee MS, Saini N, Kay CD, Neilson AP, Kwan ST, Helfrich KK, et al. An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder. Scientific Reports. January 2021, 11 (1): 248. PMID 33420159. doi:10.1038/s41598-020-80093-8.

[6] Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD. The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience: 738220. PMID 34744609. doi:10.3389/fnins.2021.738220.

[7] Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, et al. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature. February 2022, 602 (7898): 647–653. PMID 35165440. doi:10.1038/s41586-022-04396-8.

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