HIST4H4

HIST4H4
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4H9O、3WKJ、3AYW、3WA9、5B0Z、5AVB、2CV5、5AV5、3AV2、3WTP、3AV1、3AZK、3X1V、5AV8、1F66、4QUU、3CFS、4YYK、4QUT、3NQJ、3A6N、3W99、5AVC、2RS9、3F9Z、3QZT、3QBY、3W97、4M38、4YM6、3CFV、4HGA、1EQZ、2RJE、3QZV、1HQ3、4H9P、3AZL、3AFA、1TZY、3UVY、5CPK、3JPX、4U9W、4N3W、4YYJ、4YYD、4H9N、4H9R、3AZI、4LD9、3UVX、3AZH、5BNX、4N4F、1U35、4YYG、3O36、2ARO、5AV9、4H9S、3AZF、3W98、4GQB、4H9Q、5BNV、3WAA、3AZG、3AZE、2RNY、1ZKK、2QQS、2LVM、3X1T、3AN2、2KWO、3QZS、3F9W、5FFW、5CPJ、3F9X、3IJ1、4YM5、3AZJ、4YY6、3AZN、2IG0、4YYH、4YYI、5CPI、3W96、3R45、2KWN、3F9Y、5AV6、3AZM、5BO0、3X1S、4QYD、4KGC、3UVW、4YYN、3X1U、3UW9、2F8N、3NQU、5B0Y、4YYM、5C3I、4Z5T、5B24、5FA5、4Z2M、5E5A、5FWE、5B2I、5B40、5B2J、5JA4、5AY8、4ZUX
识别号
别名	H4-16；, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
外部ID	OMIM：615069 MGI：2448432 HomoloGene：134468 GeneCards：H4-16
基因位置（人类）
染色体	12号染色体
终止	14,771,131 bp
基因位置（小鼠）
染色体	小鼠13号染色体
终止	22,225,532 bp
基因本体
分子功能	• protein domain specific binding; • 血浆蛋白结合; • protein heterodimerization activity; • DNA结合; • histone binding; • RNA binding;
细胞组分	• 膜; • 染色体; • 核质; • 细胞外区域; • nuclear chromosome; • 核小体; • 外排体; • 细胞核; • 细胞外间质; • 大分子复合体;
生物学过程	• telomere organization; • epigenetic maintenance of chromatin in transcription-competent conformation; • protein heterotetramerization; • negative regulation of megakaryocyte differentiation; • CENP-A containing chromatin assembly; • DNA replication-dependent chromatin assembly; • rDNA heterochromatin assembly; • negative regulation of gene expression, epigenetic; • DNA-templated transcription, initiation; • double-strand break repair via nonhomologous end joining; • beta-catenin-TCF complex assembly; • telomere capping; • nucleosome assembly; • regulation of gene silencing by miRNA; • regulation of megakaryocyte differentiation; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	121504
	319158
	ENSG00000197837
	ENSMUSG00000060639
	P62805
	P62806
	NM_175054
	NM_175656
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	维基数据
查看/编辑人类	查看/编辑小鼠

HIST4H4为人体中的一种编码一类组蛋白H4的基因^[5]。HIST4H4没有内含子，编码组蛋白H4家族中的一种蛋白质。HIST4H4基因对应的mRNA缺乏Poly(A)尾巴。不过，这类mRNA有一个回文终止元件^[6]。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.
^ Entrez Gene: HIST4H4 histone cluster 4, H4. （原始内容存档于2019-10-17）.

拓展阅读

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Borowski P, Heiland M, Oehlmann K, et al. Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.. Eur. J. Biochem. 1996, 237 (3): 611–8. PMID 8647104. doi:10.1111/j.1432-1033.1996.0611p.x.
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Zhang Y, Sun ZW, Iratni R, et al. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol. Cell. 1998, 1 (7): 1021–31. PMID 9651585. doi:10.1016/S1097-2765(00)80102-1.
Carrier F, Georgel PT, Pourquier P, et al. Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin. Mol. Cell. Biol. 1999, 19 (3): 1673–85. PMC 83961  . PMID 10022855.
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Deng L, de la Fuente C, Fu P, et al. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. Virology. 2001, 277 (2): 278–95. PMID 11080476. doi:10.1006/viro.2000.0593.
Chadwick BP, Willard HF. A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome. J. Cell Biol. 2001, 152 (2): 375–84. PMC 2199617  . PMID 11266453. doi:10.1083/jcb.152.2.375.
Kovalsky O, Lung FD, Roller PP, Fornace AJ. Oligomerization of human Gadd45a protein. J. Biol. Chem. 2001, 276 (42): 39330–9. PMID 11498536. doi:10.1074/jbc.M105115200.
Deng L, Wang D, de la Fuente C, et al. Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. Virology. 2001, 289 (2): 312–26. PMID 11689053. doi:10.1006/viro.2001.1129.
Lahn BT, Tang ZL, Zhou J, et al. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (13): 8707–12. PMC 124363  . PMID 12072557. doi:10.1073/pnas.082248899.
Ono S, Oue N, Kuniyasu H, et al. Acetylated histone H4 is reduced in human gastric adenomas and carcinomas. J. Exp. Clin. Cancer Res. 2003, 21 (3): 377–82. PMID 12385581.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Kzhyshkowska J, Rusch A, Wolf H, Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem. J. 2003, 371 (Pt 2): 385–93. PMC 1223277  . PMID 12489984. doi:10.1042/BJ20021281.
Fujita K, Shimazaki N, Ohta Y, et al. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2004, 8 (6): 559–71. PMID 12786946. doi:10.1046/j.1365-2443.2003.00656.x.
Shiio Y, Eisenman RN. Histone sumoylation is associated with transcriptional repression. Proc. Natl. Acad. Sci. U.S.A. 2004, 100 (23): 13225–30. PMC 263760  . PMID 14578449. doi:10.1073/pnas.1735528100.
Coleman MA, Miller KA, Beernink PT, et al. Identification of chromatin-related protein interactions using protein microarrays. Proteomics. 2004, 3 (11): 2101–7. PMID 14595808. doi:10.1002/pmic.200300593.
Lusic M, Marcello A, Cereseto A, Giacca M. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J. 2004, 22 (24): 6550–61. PMC 291826  . PMID 14657027. doi:10.1093/emboj/cdg631.
Kanno T, Kanno Y, Siegel RM, et al. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol. Cell. 2004, 13 (1): 33–43. PMID 14731392. doi:10.1016/S1097-2765(03)00482-9.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12408966-5] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.

[entrez-6] Entrez Gene: HIST4H4 histone cluster 4, H4. （原始内容存档于2019-10-17）.

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