妥拉唑啉

妥拉唑啉是非選擇性競爭性α受體拮抗劑英語Alpha blocker[1]它是治療周邊血管痙攣(如手足發紺英語acrocyanosis)的血管擴張劑,也能與硝普鈉配合解除25I-NBOMe英語25I-NBOMe[2]布苯丙胺Bromodragonfly英語Bromodragonfly[3][4]5-HT2A受體英語5-HT2A receptor激動劑過量造成的嚴重血管收縮,避免壞疽。不過,它最常用作消除甲苯噻嗪鎮靜作用的獸藥[5][6]

妥拉唑啉
臨床資料
AHFS/Drugs.com國際藥品名稱
給藥途徑IV
ATC碼
識別資訊
  • 2-Benzyl-4,5-dihydro-1H-imidazole
CAS號59-98-3  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.408 編輯維基數據鏈接
化學資訊
化學式C10H12N2
摩爾質量160.22 g·mol−1
3D模型(JSmol英語JSmol
  • N\1=C(\NCC/1)Cc2ccccc2
  • InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) checkY
  • Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N checkY

參考資料

  1. ^ Aronson, J. K. Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. 2016. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm. 
  2. ^ Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935). hmdb.ca. [2022-02-03]. (原始內容存檔於2022-02-04). 
  3. ^ Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. JAMA. March 1983, 249 (11): 1477–9. PMID 6827726. doi:10.1001/jama.1983.03330350053028. 
  4. ^ Thorlacius K, Borna C, Personne M. [Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case]. Läkartidningen. 2008, 105 (16): 1199–200. PMID 18522262 (瑞典語). 
  5. ^ Boothe DM. Anticonvulsant drugs and analeptic agents. Adams HR (編). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. 2001: 378–9 [2008-09-08]. ISBN 0-8138-1743-9. 
  6. ^ Hall LW, Clarke KW, Trim CM. Principles of sedation, analgesia and premedication. Veterinary anaesthesia. Philadelphia: W.B. Saunders. 2001: 90–1. ISBN 0-7020-2035-4.