膽固醇側鏈裂解酶

膽固醇側鏈裂解酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3NA1、3N9Y、3N9Z、3NA0
識別號
別名	CYP11A1；, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
外部ID	OMIM：118485 MGI：88582 HomoloGene：37347 GeneCards：CYP11A1
相關疾病
	congenital adrenal insufficiency
為以下藥物的標靶
	米托坦、氨魯米特
基因位置（人類）
染色體	15號染色體
終止	74,367,646 bp
基因位置（小鼠）
染色體	小鼠9號染色體
終止	57,934,306 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• iron ion binding; • 金屬離子結合; • monooxygenase activity; • heme binding; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • cholesterol monooxygenase (side-chain-cleaving) activity; • 血漿蛋白結合;
細胞組分	• 膜; • 線粒體基質; • 線粒體; • mitochondrial inner membrane;
生物學過程	• vitamin D metabolic process; • C21-steroid hormone metabolic process; • 脂質代謝; • cholesterol metabolic process; • C21-steroid hormone biosynthetic process; • sterol metabolic process; • steroid biosynthetic process; • steroid metabolic process; • glucocorticoid biosynthetic process; • cellular response to peptide hormone stimulus; • cortisol metabolic process;
	Sources:Amigo / QuickGO
直系同源
	1583
	13070
	ENSG00000140459; ENSG00000288362
	ENSMUSG00000032323
	P05108
	Q9QZ82
	NM_001099773; NM_000781
	NM_019779; NM_001346787
	NP_000772; NP_001093243
	NP_001333716; NP_062753
	維基數據
檢視/編輯人類	檢視/編輯小鼠

膽固醇側鏈裂解酶（英語：Cholesterol side-chain cleavage enzyme，CYP11A1或P450scc，其中「scc」是「side-chain 側鏈」「cleavage 裂解」的縮寫）是一種將膽固醇轉化為孕烯醇酮的線粒體酶。這是所有哺乳動物中由膽固醇生成各種甾類激素的第一步反應^[7]。

膽固醇 + 3 NADPH + 3 H⁺ + 3 O₂ ⇄ 孕烯醇酮 + 4-甲基戊醛 + 3 NADP⁺ + 3 H₂O

P450scc 是細胞色素P450氧化酶超家族的一員（家族11亞家族A多肽1），基因名為 CYP11A1^[8]。

另見

參考文獻

^ 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考.
^ 對胆固醇侧链裂解酶起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000140459、ENSG00000288362 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
^ Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.

延伸閱讀

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Sparkes RS, Klisak I, Miller WL. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. DNA and Cell Biology. June 1991, 10 (5): 359–65. PMID 1863359. doi:10.1089/dna.1991.10.359.
Coghlan VM, Vickery LE. Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc. The Journal of Biological Chemistry. October 1991, 266 (28): 18606–12. PMID 1917982.
Matteson KJ, Chung BC, Urdea MS, Miller WL. Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probes. Endocrinology. April 1986, 118 (4): 1296–305. PMID 2419119. doi:10.1210/endo-118-4-1296.
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proceedings of the National Academy of Sciences of the United States of America. December 1986, 83 (23): 8962–6. PMC 387054  . PMID 3024157. doi:10.1073/pnas.83.23.8962.
Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y. Gene structure of human cytochrome P-450(SCC), cholesterol desmolase. Journal of Biochemistry. April 1987, 101 (4): 879–87. PMID 3038854.
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[1] 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考.

[2] 對胆固醇侧链裂解酶起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000140459、ENSG00000288362 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid22217824-7] Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.

[entrez-8] Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.

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