維基百科

甘露糖受體

甘露糖受體（英語：Mannose receptor）是一類C-型凝集素，主要在巨噬細胞、未成熟樹突狀細胞和肝竇內皮細胞表面表達[1]，在角質形成細胞、真皮成纖維細胞（英語：Dermal fibroblast）等皮膚細胞上也有表達[2]。人類基因組中共有2個甘露糖受體基因：CD206（甘露糖受體1型，MRC1）和CD280（甘露糖受體2型，MRC2）。此外，甘露糖受體家族還包括CD205、PLA2R1[3]以及CD302[4]。

Macrophage mannose receptor
鑑定
標誌MMR
膜蛋白數據庫（英語：Membranome）56
mannose receptor, C type 1
識別
符號 MRC1
替換符號 CD206
Entrez 4360
HUGO 7228
OMIM 153618
RefSeq NM_002438
UniProt P22897
其他資料
基因座 10 p13
mannose receptor, C type 2
識別
符號 MRC2
替換符號 CD280
Entrez 9902
HUGO 16875
RefSeq NM_006039
UniProt Q9UBG0
其他資料
基因座 17 q23
Pymol image of the mannose receptor N-terminal cystein-rich domain bound to its sulphated N-Acetylgalactosamine ligand. The sulphated ligand fits snugly into a pocket on the surface of the cysteine-rich domain
甘露糖受體N-末端富半胱氨酸結構域（粉色）與N-乙酰半乳糖胺（青色）結合
The extracellular portion of the mannose receptor contains an N-terminal cystein-rich domain, a fibronectin type II domain and 8 C-type carbohydrate recognition domains. This is followed by a transmembrane region and a short cytoplasmic C-terminal tail
甘露糖受體的各個結構域[5]

參考文獻

  1. ^ Szolnoky G, Bata-Csörgö Z, Kenderessy AS, Kiss M, Pivarcsi A, Novák Z, Nagy Newman K, Michel G, Ruzicka T, Maródi L, Dobozy A, Kemény L. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans. Journal of Investigative Dermatology. August 2001, 117 (2): 205–13. PMID 11511295. doi:10.1046/j.1523-1747.2001.14071.x  . 
  2. ^ Sheikh H, Yarwood H, Ashworth A, Isacke CM. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. Journal of Cell Science. March 2000, 113 (6): 1021–32. PMID 10683150. doi:10.1242/jcs.113.6.1021. 
  3. ^ East L, Isacke CM. The mannose receptor family. Biochimica et Biophysica Acta (BBA) - General Subjects. 2002, 1572 (2–3): 364–86. PMID 12223280. doi:10.1016/S0304-4165(02)00319-7. 
  4. ^ Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. J. Immunol. November 2007, 179 (9): 6052–63. PMID 17947679. doi:10.4049/jimmunol.179.9.6052  . 
  5. ^ Taylor M, Drickamer K. Introduction to Glycobiology. Oxford University Press. 2011. ISBN 978-0-19-956911-3. 

外部連結

取自「https://zh.wikipedia.org/w/index.php?title=甘露糖受体&oldid=84963537」