CXCR5

Chemokine (C-X-C motif) receptor 5
趋化因子（C-X-C基序）受体5
Chemokine (C-X-C motif) receptor 5; 趋化因子（C-X-C基序）受体5
标识
代号	CXCR5; BLR1; CD185; MDR15
扩展标识	遗传学：601613 鼠基因：103567 同源基因：1298 IUPHAR: CXCR5 ChEMBL: 1075315 GeneCards: CXCR5 Gene
基因本体论描述
分子功能	· G-protein coupled receptor activity; · protein binding; · C-X-C chemokine receptor activity;
细胞成分	· plasma membrane; · integral component of plasma membrane;
生物过程	· cellular component movement; · chemotaxis; · immune response; · G-protein coupled receptor signaling pathway; · positive regulation of cytokinesis; · B cell activation; · lymph node development; · chemokine-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	643
Ensembl	ENSG00000160683
UniProt	P32302
mRNA序列	NM_001716
蛋白序列	NP_001707
基因位置	Chr 11:; 118.75 – 118.77 Mb
PubMed查询	[1]
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C-X-C趋化因子受体5（英语：C-X-C chemokine receptor type 5，CXC-R5）也被称为CD185（分化簇185）或伯基特淋巴瘤受体1（英语：Burkitt lymphoma receptor 1，BLR1）是一种G蛋白偶联的七跨膜受体，属于CXC趋化因子受体家族，其配体为趋化因子CXCL13（也被称为BLC）。在人类中，CXC-R5蛋白质由 CXCR5 基因编码^[1]。

组织分布与功能

BLR1 / CXCR5 基因特异性表达于伯基特淋巴瘤以及其它淋巴组织，比如淋巴结和脾脏中的淋巴滤泡。该基因对B细胞的迁移起到重要作用^[2]。

临床意义

T细胞会表达CD4⁺CXCR5⁺以对抗结核杆菌（Mtb）感染^[3]。

参考文献

^ Dobner T, Wolf I, Emrich T, Lipp M. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. November 1992, 22 (11): 2795–9. PMID 1425907. doi:10.1002/eji.1830221107.
^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996, 87 (6): 1037–47. PMID 8978608. doi:10.1016/S0092-8674(00)81798-5.
^ Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. CXCR5+ T helper cells mediate protective immunity against tuberculosis. J. Clin. Invest. January 2013. PMC 3561804  . PMID 23281399. doi:10.1172/JCI65728.

延伸阅读

Lipp M, Müller G. Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.. Verhandlungen der Deutschen Gesellschaft für Pathologie. 2006, 87: 90–101. PMID 16888899.
Barella L, Loetscher M, Tobler A; et al. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.. Biochem. J. 1995, 309 (3): 773–9. PMC 1135699  . PMID 7639692.
Legler DF, Loetscher M, Roos RS; et al. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.. J. Exp. Med. 1998, 187 (4): 655–60. PMC 2212150  . PMID 9463416. doi:10.1084/jem.187.4.655.
Gunn MD, Ngo VN, Ansel KM; et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.. Nature. 1998, 391 (6669): 799–803. PMID 9486651. doi:10.1038/35876.
Müller G, Lipp M. Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules.. Biol. Chem. 2002, 382 (9): 1387–97. PMID 11688722. doi:10.1515/BC.2001.171.
Schaerli P, Loetscher P, Moser B. Cutting edge: induction of follicular homing precedes effector Th cell development.. J. Immunol. 2002, 167 (11): 6082–6. PMID 11714765. doi:10.4049/jimmunol.167.11.6082.
Kim CH, Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.. Blood. 2002, 100 (1): 11–6. PMID 12070001. doi:10.1182/blood-2001-12-0196.
Carlsen HS, Baekkevold ES, Johansen FE; et al. B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.. Gut. 2002, 51 (3): 364–71. PMC 1773345  . PMID 12171958. doi:10.1136/gut.51.3.364.
Battle TE, Yen A. Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.. Exp. Biol. Med. (Maywood). 2002, 227 (9): 753–62. PMID 12324654.
Lisignoli G, Toneguzzi S, Piacentini A; et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release.. J. Cell. Physiol. 2003, 194 (1): 71–9. PMID 12447991. doi:10.1002/jcp.10188.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899.
Chan CC, Shen D, Hackett JJ; et al. Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma.. Ophthalmology. 2003, 110 (2): 421–6. PMID 12578791. doi:10.1016/S0161-6420(02)01737-2.
Flynn G, Maru S, Loughlin J; et al. Regulation of chemokine receptor expression in human microglia and astrocytes.. J. Neuroimmunol. 2003, 136 (1-2): 84–93. PMID 12620646. doi:10.1016/S0165-5728(03)00009-2.
Lisignoli G, Piacentini A, Toneguzzi S; et al. Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts.. Biogerontology. 2004, 4 (5): 309–17. PMID 14618028. doi:10.1023/A:1026203502385.
Aust G, Sittig D, Becherer L; et al. The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases.. Eur. J. Endocrinol. 2004, 150 (2): 225–34. PMID 14763921. doi:10.1530/eje.0.1500225.
Howard OM, Dong HF, Su SB; et al. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.. Blood. 2005, 105 (11): 4207–14. PMC 1895027  . PMID 15713799. doi:10.1182/blood-2004-07-2697.
Steinmetz OM, Panzer U, Kneissler U; et al. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection.. Kidney Int. 2005, 67 (4): 1616–21. PMID 15780119. doi:10.1111/j.1523-1755.2005.00244.x.
Hu C, Xiong J, Zhang L; et al. PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia.. Cell. Mol. Immunol. 2006, 1 (4): 280–94. PMID 16225771.

[pmid1425907-1] Dobner T, Wolf I, Emrich T, Lipp M. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. November 1992, 22 (11): 2795–9. PMID 1425907. doi:10.1002/eji.1830221107.

[pmid8978608-2] Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996, 87 (6): 1037–47. PMID 8978608. doi:10.1016/S0092-8674(00)81798-5.

[pmid23281399-3] Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. CXCR5+ T helper cells mediate protective immunity against tuberculosis. J. Clin. Invest. January 2013. PMC 3561804  . PMID 23281399. doi:10.1172/JCI65728.

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