谷氨酰氨基肽酶
谷氨酰氨基肽酶，又称氨基肽酶A，旧称血管紧张素酶A[1]。它由ENPEP基因编码，且高度保守[2]。谷氨酰氨基肽酶是一种膜结合锌蛋白，能催化谷氨酸和天冬氨酸从肽链的N末端水解。例如，把血管紧张素IIN末端天冬氨酸水解而转化血管紧张素III。这个降解过程是哺乳动物调节局部血压的一个重要步骤[1][3]。谷氨酰氨基肽酶被指定为CD249。
| 谷氨酰氨基肽酶 (氨基肽酶A) | |
|---|---|
| 识别 | |
| 符号 | ENPEP |
| 替换符号 | gp160, CD249 |
| Entrez | 2028 |
| HUGO | 3355 |
| OMIM | 138297 |
| RefSeq | NM_001977 |
| UniProt | Q07075 |
| 其他资料 | |
| EC编号 | 3.4.11.7 |
| 基因座 | 4 q25 |
参考文献
- ^ 1.0 1.1 Kugler P. Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate.. Histochemistry. 1982, 74 (2): 247–61. PMID 6129208.
- ^ Li L, Wu Q, Wang J, Bucy RP, Cooper MD. Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody.. Tissue Antigens. 1993, 42 (5): 488 – 96. PMID 8146860.
- ^ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C. Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem. Soc. Trans. 2000, 28 (4): 435–40. PMID 10961935.