去炎松

化合物

去炎松(英语:triamcinolone)又叫氟羟氢化泼尼松曲安西龙,是长效合成的皮质类固醇,可口服、注射、吸入或制成软膏外用。可用来治疗湿疹银屑病关节炎过敏溃疡性大肠炎(Ulcerative colitis)、红斑性狼疮交感性眼炎巨大细胞动脉炎(Giant cell arteritis)、葡萄膜炎(Uveitis)、眼炎的治疗,玻璃体切除时的呈像及预防哮喘等,但其无法在哮喘发作后作出有效治疗[1][2][3]

去炎松
临床资料
商品名英语Drug nomenclatureKenalog
其他名称
Click show to see
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
AHFS/Drugs.comMonograph
怀孕分级
  • : A
给药途径Oral, topical, IM, intra-articular, intrasynovial
ATC码
法律规范状态
法律规范
药物动力学数据
血浆蛋白结合率68%
药物代谢Hepatic
生物半衰期88 minutes
排泄途径Fecal and renal
识别信息
  • (11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
CAS号124-94-7  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.004.290 编辑维基数据链接
化学信息
化学式C21H27FO6
摩尔质量394.434 g/mol
3D模型(JSmol英语JSmol
  • O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3O)C)C
  • InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1 checkY
  • Key:GFNANZIMVAIWHM-OBYCQNJPSA-N checkY

参考文献

  1. ^ Triamcinolone - Drugs.com. [2011-12-06]. (原始内容存档于2017-07-16). 
  2. ^ Triamcinolone Inhalation - Drugs.com. [2011-12-06]. (原始内容存档于2016-04-09). 
  3. ^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com. [2011-12-06]. (原始内容存档于2017-02-02).