依美斯汀

化合物

依美斯汀[2](emedastine),商品名埃美丁[3](Emadine),是第二代抗组织胺,可用作眼药水以减缓过敏性结膜炎的症状。依美斯汀属于H1 接收器抑制剂。借由抑制组织胺的作用来减缓过敏性结膜炎的症状。当依美斯汀用作眼药水时,会以双延胡索酸盐(difumarate)的形式存在[4]

依美斯汀
临床资料
商品名英语Drug nomenclatureEmadine
AHFS/Drugs.comMonograph
核准状况
给药途径局部外用 (眼药水)
ATC码
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
生物利用度~50% (口服) (Tmax英语Cmax (pharmacology) = 1–2 小时)[1]
药物代谢肝脏
生物半衰期3–4 小时 (口服); 10 小时 (局部外用)
识别信息
  • 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-benzimidazole
CAS号87233-61-2  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C17H26N4O
摩尔质量302.415 g/mol
3D模型(JSmol英语JSmol
  • O(CC)CCn1c(nc2ccccc12)N3CCCN(C)CC3
  • InChI=1S/C17H26N4O/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20/h4-5,7-8H,3,6,9-14H2,1-2H3 checkY
  • Key:KBUZBQVCBVDWKX-UHFFFAOYSA-N checkY

文献来源

  1. ^ Emadine (emedastine difumarate ophthalmic solution) 0.05%. Full Prescribing Information (PDF). Alcon Laboratories, Inc. 6201 South Freeway Fort Worth, Texas 76134, USA. [5 January 2016]. (原始内容存档 (PDF)于2019-08-06). 
  2. ^ https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9OGVhZDg5ZDg1MTExYzNkMzgyMmM1ZTdkM2EwMTBhN2ImaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MDg4MWY4NDgxNzlm
  3. ^ https://www.nmpa.gov.cn/datasearch/search-info.html?nmpa=aWQ9ZjBiM2FiNzUwNDE5ZDU4MDY5ODNiNjBjMWJiZGI3NGQmaXRlbUlkPWZmODA4MDgxODNjYWQ3NTAwMTg0MTI1MTE3NWExZWRi
  4. ^ Bielory, L.; Lien, K. W.; Bigelsen, S. Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs. 2005, 65 (2): 215–228. PMID 15631542. doi:10.2165/00003495-200565020-00004.