妥拉唑啉

妥拉唑啉是非选择性竞争性α受体拮抗剂英语Alpha blocker[1]它是治疗周边血管痉挛(如手足发绀英语acrocyanosis)的血管扩张剂,也能与硝普钠配合解除25I-NBOMe英语25I-NBOMe[2]布苯丙胺Bromodragonfly英语Bromodragonfly[3][4]5-HT2A受体英语5-HT2A receptor激动剂过量造成的严重血管收缩,避免坏疽。不过,它最常用作消除甲苯噻嗪镇静作用的兽药[5][6]

妥拉唑啉
臨床資料
AHFS/Drugs.com国际药品名称
给药途径IV
ATC碼
识别信息
  • 2-Benzyl-4,5-dihydro-1H-imidazole
CAS号59-98-3  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.408 編輯維基數據鏈接
化学信息
化学式C10H12N2
摩尔质量160.22 g·mol−1
3D模型(JSmol英语JSmol
  • N\1=C(\NCC/1)Cc2ccccc2
  • InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) checkY
  • Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N checkY

参考资料

  1. ^ Aronson, J. K. Meyler's side effects of drugs : the international encyclopedia of adverse drug reactions and interactions. Amsterdam: Elsevier Science. 2016. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm. 
  2. ^ Human Metabolome Database: Showing metabocard for Tolazoline (HMDB0014935). hmdb.ca. [2022-02-03]. (原始内容存档于2022-02-04). 
  3. ^ Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. JAMA. March 1983, 249 (11): 1477–9. PMID 6827726. doi:10.1001/jama.1983.03330350053028. 
  4. ^ Thorlacius K, Borna C, Personne M. [Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case]. Läkartidningen. 2008, 105 (16): 1199–200. PMID 18522262 (瑞典语). 
  5. ^ Boothe DM. Anticonvulsant drugs and analeptic agents. Adams HR (编). Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. 2001: 378–9 [2008-09-08]. ISBN 0-8138-1743-9. 
  6. ^ Hall LW, Clarke KW, Trim CM. Principles of sedation, analgesia and premedication. Veterinary anaesthesia. Philadelphia: W.B. Saunders. 2001: 90–1. ISBN 0-7020-2035-4.