单加氧酶

单加氧酶(英語:Monooxygenase)又称單氧化酶混合功能氧化酶(mixed functional oxidase),在多种代谢途径中催化一分子氧(O2)中的一个氧原子与底物结合,形成一个羟基(发生羟化)的产物;另一个氧原子被还原形成一分子水,并同时伴随着NADHNADPH的氧化[2][3]

单加氧酶
Structure of the Tetx Monooxygenase in complex with the substrate 7-Iodtetracycline.[1]
鑑定
標誌FAD_binding_3
PfamPF01494旧版
InterPro英语InterProIPR002938
SCOP英语Structural Classification of Proteins2phh / SUPFAM

参考文献

  1. ^ PDB 2Y6Q; Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W. Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. FEBS Lett. April 2011, 585 (7): 1061–6. PMID 21402075. doi:10.1016/j.febslet.2011.03.012. 
  2. ^ Harayama S, Kok M, Neidle EL. Functional and evolutionary relationships among diverse oxygenases. Annu. Rev. Microbiol. 1992, 46: 565–601. PMID 1444267. doi:10.1146/annurev.mi.46.100192.003025. 
  3. ^ Schreuder HA, van Berkel WJ, Eppink MH, Bunthol C. Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability. FEBS Lett. 1999, 443 (3): 251–255. PMID 10025942. doi:10.1016/S0014-5793(98)01726-8. 

外部链接

此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR002938