VUAA1

化合物

VUAA1是一种昆虫嗅觉共受体激动剂型驱虫剂[1][2]。由美国范德比尔特大学比尔及梅琳达·盖茨基金会部分资助下发现[3][4]

VUAA1
IUPAC名
N-(4-Ethylphenyl)-2-{[4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
识别
CAS号 525582-84-7  checkY
PubChem 1319135
ChemSpider 1105882
SMILES
 
  • CCN1C(C2=CN=CC=C2)=NN=C1SCC(NC3=CC=C(CC)C=C3)=O
性质
化学式 C19H21N5OS
摩尔质量 367.47 g·mol−1
危险性
GHS危险性符号
《全球化学品统一分类和标签制度》(简称“GHS”)中有害物质的标签图案
GHS提示词 Warning
H-术语 H315, H319, H335
P-术语 P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

VUAA1被认为是通过强力刺激昆虫嗅觉受体来实现驱虫效果,且效力约为避蚊胺的1000倍[5],并可能导致“开创一个强大的新驱虫剂类型,用于消灭有害昆虫、农业害虫和病媒等的破坏行为”[6]

VUAA1还展示出刺激蚊子精子活力的特性,从而表明蚊子的嗅觉和繁殖之间的联系[7]

参考文献

  1. ^ Medicine, Vanderbilt University School of. Allosteric antagonism of insect odorant receptor ion channels. | Chemical Synthesis Core. medschool.vanderbilt.edu. [2016-06-02]. 
  2. ^ 向婧洁、钟延强、樊莉、鲁莹. 蚊虫驱避剂新进展. 中国媒介生物学及控制杂志. 2013, 24 (1): 79–82. 
  3. ^ Jones, P. L.; Pask, G. M.; Rinker, D. C.; Zwiebel, L. J. Functional agonism of insect odorant receptor ion channels. Proceedings of the National Academy of Sciences. 2011, 108 (21): 8821–5. Bibcode:2011PNAS..108.8821J. PMC 3102409 . PMID 21555561. doi:10.1073/pnas.1102425108 . 
  4. ^ Doug Gross. A bug repellent that could save lives - CNN.com. CNN. 5 May 2014 [2016-06-02]. 
  5. ^ New type of insect repellent may be thousands of times stronger than DEET (新闻稿). physorg.com. May 9, 2011. 
  6. ^ Functional agonism of insect odorant receptor ion channel (PDF) (新闻稿). April 4, 2011. 
  7. ^ VICB Article: Sulfilimine Cross-Links A Key to Tissue Evolution. www.vanderbilt.edu. [2016-06-02].