PH结构域

PH结构域(英語:PH domain,全称普列克底物蛋白同源结构域Pleckstrin homology domain)是一类蛋白质结构域,长约120个氨基酸,存在于涉及细胞内信号传导或作为细胞骨架成分的多种蛋白质中。[1][2][3][4][5][6][7]

鑑定
標誌PH
PfamPF00169旧版
Pfam宗系CL0266旧版
InterPro英语InterProIPR001849
SMART英语Simple Modular Architecture Research ToolPH
PROSITE英语PROSITEPDOC50003
SCOP英语Structural Classification of Proteins1dyn / SUPFAM
OPM英语Orientations of Proteins in Membranes database家族49
OPM英语Orientations of Proteins in Membranes database蛋白1pls
CDD英语Conserved Domain Databasecd00821

参考文献

  1. ^ Mayer BJ, Ren R, Clark KL, Baltimore D. A putative modular domain present in diverse signaling proteins. Cell. May 1993, 73 (4): 629–30. PMID 8500161. S2CID 44282241. doi:10.1016/0092-8674(93)90244-K. 
  2. ^ Haslam RJ, Koide HB, Hemmings BA. Pleckstrin domain homology. Nature. May 1993, 363 (6427): 309–10. PMID 8497315. S2CID 4334376. doi:10.1038/363309b0. 
  3. ^ Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends in Biochemical Sciences. September 1993, 18 (9): 343–8. PMID 8236453. doi:10.1016/0968-0004(93)90071-T. 
  4. ^ Gibson TJ, Hyvönen M, Musacchio A, Saraste M, Birney E. PH domain: the first anniversary. Trends in Biochemical Sciences. September 1994, 19 (9): 349–53. PMID 7985225. doi:10.1016/0968-0004(94)90108-2. 
  5. ^ Pawson T. Protein modules and signalling networks. Nature. February 1995, 373 (6515): 573–80. PMID 7531822. S2CID 4324726. doi:10.1038/373573a0. 
  6. ^ Ingley E, Hemmings BA. Pleckstrin homology (PH) domains in signal transduction. Journal of Cellular Biochemistry. December 1994, 56 (4): 436–43. PMID 7890802. doi:10.1002/jcb.240560403. 
  7. ^ Saraste M, Hyvönen M. Pleckstrin homology domains: a fact file. Current Opinion in Structural Biology. June 1995, 5 (3): 403–8. PMID 7583640. doi:10.1016/0959-440X(95)80104-9. 

外部链接