NITD008
化合物
NITD008是一种抗病毒药物，属于腺苷类似物（一种核苷类似物）。它作为治疗黄病毒感染的潜在药物被开发，并显示出对很多相关病毒的广谱活性，如骨痛热症病毒、西尼羅河病毒、黄热病病毒、波瓦桑病毒、丙肝病毒、克亚萨努尔森林病病毒、鄂木斯克出血热病毒和茲卡病毒。[1][2][3]然而，虽然NITD008在临床前的动物试验中显示出较大毒性，不适合人体试验，但是它仍被用于新型病毒性疾病治疗的研究中。[4]
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| 臨床資料 | |
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| 商品名 | NITD008 |
| 识别信息 | |
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| CAS号 | 1044589-82-3  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C13H14N4O4 |
| 摩尔质量 | 290.28 g·mol−1 |
| 3D模型（JSmol） | |
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参考文献
- ^ Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, et al. An adenosine nucleoside inhibitor of dengue virus. Proceedings of the National Academy of Sciences of the United States of America. December 2009, 106 (48): 20435–9. Bibcode:2009PNAS..10620435Y. PMC 2787148
. PMID 19918064. doi:10.1073/pnas.0907010106 .
- ^ Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF. In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. Antiviral Research. June 2016, 130: 46–9. PMC 5096641 . PMID 27016316. doi:10.1016/j.antiviral.2016.03.013.
- ^ Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, et al. Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus. Open Forum Infectious Diseases. October 2016, 3 (4): ofw175. PMC 5063548 . PMID 27747251. doi:10.1093/ofid/ofw175 .
- ^ Nelson J, Roe K, Orillo B, Shi PY, Verma S. Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection. Antiviral Research. October 2015, 122: 39–45. PMC 4853296 . PMID 26225754. doi:10.1016/j.antiviral.2015.07.008.
