HT1080細胞

HT1080是一種纖維肉瘤英语Fibrosarcoma細胞系,在生物醫學研究英语Medical research中得到廣泛應用。該細胞系是由一名35歲的男性患者的纖維肉瘤活檢組織中提取的[1],患者未接受放射線療法化學療法,因此將不必要的突變引入細胞系的可能性降低。有研究發現該細胞系帶有IDH1英语IDH1突變和已活化N-ras英语Neuroblastoma RAS viral oncogene homolog癌基因[2]

HT1080細胞

參考資料

  1. ^ Rasheed, S; Nelson-Rees, WA; Toth, EM; Arnstein, P; Gardner, MB. Characterization of a newly derived human sarcoma cell line (HT-1080).. Cancer. 1974-04, 33 (4): 1027–33 [2019-11-29]. PMID 4132053. doi:10.1002/1097-0142(197404)33:4<1027::aid-cncr2820330419>3.0.co;2-z. 
  2. ^ Benedict, WF; Weissman, BE; Mark, C; Stanbridge, EJ. Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.. Cancer research. 1984-08, 44 (8): 3471–9 [2019-11-29]. PMID 6744274. 

外部連結