C5a受体
C5a受体(英語:C5a receptor或称补体成分5a受体1,complement component 5a receptor 1,C5AR1或CD88,Cluster of Differentiation 88)是一种与补体C5a相结合的G蛋白偶联受体[5]。
![](http://images.weserv.nl/?url=//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/C5a-receptor.png/450px-C5a-receptor.png)
细胞
C5a受体表达于以下细胞:[6]
另见
参考文献
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000197405 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000049130 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994, 12: 775–808. PMID 8011297. doi:10.1146/annurev.iy.12.040194.004015.
- ^ Klos A, Wende E, Wareham KJ, Monk PN. International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 2013, 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223.
延伸阅读
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- Bao L, Gerard NP, Eddy RL; et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.. Genomics. 1992, 13 (2): 437–40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T.
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- Foreman KE, Vaporciyan AA, Bonish BK; et al. C5a-induced expression of P-selectin in endothelial cells.. J. Clin. Invest. 1994, 94 (3): 1147–55. PMC 295185 . PMID 7521884. doi:10.1172/JCI117430.
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- Ames RS, Li Y, Sarau HM; et al. Molecular cloning and characterization of the human anaphylatoxin C3a receptor.. J. Biol. Chem. 1996, 271 (34): 20231–4. PMID 8702752. doi:10.1074/jbc.271.34.20231.
- Werfel T, Zwirner J, Oppermann M; et al. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 1996, 157 (4): 1729–35. PMID 8759762.
- Höpken UE, Lu B, Gerard NP, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection.. Nature. 1996, 383 (6595): 86–9. PMID 8779720. doi:10.1038/383086a0.
- Chen Z, Zhang X, Gonnella NC; et al. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 1998, 273 (17): 10411–9. PMID 9553099. doi:10.1074/jbc.273.17.10411.
- Floreani AA, Heires AJ, Welniak LA; et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 1998, 160 (10): 5073–81. PMID 9590258.
- Ottonello L, Corcione A, Tortolina G; et al. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.. J. Immunol. 1999, 162 (11): 6510–7. PMID 10352266.
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- Monk PN, Scola A-M, Madala P, Fairlie DP. Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology. 2007, 152 (4): 429–48. PMC 2050825 . PMID 17603557. doi:10.1038/sj.bjp.0707332.
外部链接
- Anaphylatoxin Receptors: C5a. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. (原始内容存档于2014-04-07).
- 醫學主題詞表(MeSH):C5a+receptors