硝唑尼特
化合物
(重定向自C12H9N3O5S)
硝唑尼特是一种抗寄生虫药和抗病毒藥,用于治疗由寄生虫、原生動物、小隱孢子蟲、兰氏贾第鞭毛虫、芽囊原虫属[4][5]、溶组织内阿米巴[6]、蛔虫[7]和病毒引起的感染。 [8][9][10] 它還能治疗流行性感冒[1][10]以及慢性乙型肝炎[11]。
臨床資料 | |
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商品名 | Alinia, Nizonide, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603017 |
核准狀況 | |
给药途径 | By mouth |
藥物類別 | Antiprotozoal Broad-spectrum antiparasitic Broad-spectrum antiviral |
ATC碼 | |
法律規範狀態 | |
法律規範 | |
藥物動力學數據 | |
血漿蛋白結合率 | Nitazoxanide: ? Tizoxanide: over 99%[1][2] |
药物代谢 | Rapidly hydrolyzed to tizoxanide[1] |
代謝產物 | tizoxanide[1][2] tizoxanide glucuronide[1][2] |
生物半衰期 | 3.5 hours[3] |
排泄途徑 | Kidney, bile duct, and fecal[1] |
识别信息 | |
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CAS号 | 55981-09-4 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
NIAID ChemDB | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.054.465 |
化学信息 | |
化学式 | C12H9N3O5S |
摩尔质量 | 307.28 g·mol−1 |
3D模型(JSmol) | |
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参考文献
- ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Alinia- nitazoxanide tablet Alinia- nitazoxanide powder, for suspension. DailyMed. [13 February 2021]. (原始内容存档于2021-03-20).
- ^ 2.0 2.1 2.2 Stockis A, Allemon AM, De Bruyn S, Gengler C. Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses. International Journal of Clinical Pharmacology and Therapeutics. May 2002, 40 (5): 213–220. PMID 12051573. doi:10.5414/cpp40213.
- ^ Nitazoxanide. PubChem. National Center for Biotechnology Information, U.S. National Library of Medicine. [3 January 2016]. (原始内容存档于2016-03-06).
- ^ Blastocystis: Resources for Health Professionals. United States Centers for Disease Control and Prevention. 2017-05-02 [4 January 2016]. (原始内容存档于2015-11-08).
- ^ Roberts T, Stark D, Harkness J, Ellis J. Update on the pathogenic potential and treatment options for Blastocystis sp. Gut Pathogens. May 2014, 6: 17 [2023-11-18]. PMC 4039988 . PMID 24883113. doi:10.1186/1757-4749-6-17 . (原始内容存档于2022-11-11).
Blastocystis is one of the most common intestinal protists of humans. ... A recent study showed that 100% of people from low socio-economic villages in Senegal were infected with Blastocystis sp. suggesting that transmission was increased due to poor hygiene sanitation, close contact with domestic animals and livestock, and water supply directly from well and river [10]. ...
- ^ Muñoz P, Valerio M, Eworo A, Bouza E. Parasitic infections in solid-organ transplant recipients. Current Opinion in Organ Transplantation. December 2011, 16 (6): 565–575. PMID 22027588. S2CID 23861504. doi:10.1097/MOT.0b013e32834cdbb0.
Nitazoxanide: intestinal amoebiasis: 500 mg po bid x 3 days
- ^ Hagel I, Giusti T. Ascaris lumbricoides: an overview of therapeutic targets. Infectious Disorders Drug Targets. October 2010, 10 (5): 349–367. PMID 20701574. S2CID 15403331. doi:10.2174/187152610793180876.
new anthelmintic alternatives such as tribendimidine and Nitazoxanide have proved to be safe and effective against A. lumbricoides and other soil-transmitted helminthiases in human trials.
- ^ Di Santo N, Ehrisman J. Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?. Cancers. September 2013, 5 (3): 1163–1176. PMC 3795384 . PMID 24202339. doi:10.3390/cancers5031163 .
Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed of a nitrothiazole-ring and a salicylic acid moiety which are linked together by an amide bond ... NTZ is generally well tolerated, and no significant adverse events have been noted in human trials [13]. ... In vitro, NTZ and tizoxanide function against a wide range of organisms, including the protozoal species Blastocystis hominis, C. parvum, Entamoeba histolytica, G. lamblia and Trichomonas vaginalis [13]
- ^ White CA. Nitazoxanide: a new broad spectrum antiparasitic agent. Expert Review of Anti-Infective Therapy. February 2004, 2 (1): 43–49. PMID 15482170. S2CID 219184877. doi:10.1586/14787210.2.1.43.
- ^ Teran CG, Teran-Escalera CN, Villarroel P. Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: a randomized, single-blind, controlled trial in Bolivian children. International Journal of Infectious Diseases. July 2009, 13 (4): 518–523. PMID 19070525. doi:10.1016/j.ijid.2008.09.014 .