AZD0328

化合物

AZD0328是一种开发中的药物,分子式C13H16N2O,是一种选择性的α7菸鹼興奮劑,会增强脑皮层的多巴胺释放,改善大鼠的学习和注意力过程[1]

AZD0328
法律規範狀態
法律規範
  • Investigational
识别信息
  • 3′H‐4‐Azaspiro[bicyclo[2.2.2]octane‐2,2'‐furo[2,3‐b]pyridine]
CAS号220099-91-2  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C13H16N2O
摩尔质量216.28 g·mol−1
3D模型(JSmol英语JSmol
  • C1C2=CC=CN=C2OC11CN2CCC1CC2
  • InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1 checkY
  • Key:OCKIPDMKGPYYJS-ZDUSSCGKSA-N checkY

它可以3-奎宁环酮德语3-Chinuclidinon2-氯吡啶为原料经多步反应制得。[2]

参考文献

  1. ^ Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, et al. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochemical Pharmacology. October 2009, 78 (7): 880–8. PMID 19615981. doi:10.1016/j.bcp.2009.07.005. 
  2. ^ Loch, James, III; Mullen, George; Phillips, Eifion. Preparation of furopyridineamines as nicotinic receptor agonists. 2000. WO 2000042044 A1.

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