ASP2535甘氨酸转运蛋白1英语Glycine transporter 1的抑制剂,[1]阿尔茨海默病精神分裂症上有治疗研究。

ASP2535
IUPAC名
4-[3-(6-phenylpyridin-3-yl)-5-propan-2-yl-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
识别
CAS号 374886-51-8  checkY
PubChem 9800113
SMILES
 
  • CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5
性质
化学式 C22H18N6O
摩尔质量 382.42 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

它可以6-苯基烟酸,4-氨基苯并呋咱和2-甲基丙酰肼为原料经多步反应制得。[2]

参考文献

  1. ^ Harada, Katsuya; Nakato, Kazuhiro; Yarimizu, Junko; Yamazaki, Mayako; Morita, Masahiko; Takahashi, Shinji; Aota, Masaki; Saita, Kyoko; Doihara, Hitoshi; Sato, Yuichiro; Yamaji, Takayuki; Ni, Keni; Matsuoka, Nobuya. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. European Journal of Pharmacology. 2012-06-15, 685 (1–3): 59–69. ISSN 1879-0712. PMID 22542656. doi:10.1016/j.ejphar.2012.04.013. 
  2. ^ Sano, Kuniyuki; Sakaida, Uro. Process for preparation of benzoxadiazole compound. 2009. JP2009280554.