3-吡啶乙酸

化合物

3-吡啶乙酸是一种有机化合物,化学式为C7H7NO2,它是三种吡啶乙酸同分异构体之一。它可由3-溴甲基吡啶一氧化碳Pd(OH)2/C的催化下反应得到。[2]它和乙醇硫酸催化下反应,可以得到3-吡啶乙酸乙酯。[3]它在乙酸铜催化下、氧气存在下脱羧,得到吡啶-3-甲醛[4]

3-吡啶乙酸
识别
CAS号 501-81-5  checkY
性质
化学式 C7H7NO2
摩尔质量 137.14 g·mol−1
熔点 144—146 °C(417—419 K)[1]
相关物质
相关化学品 苯乙酸
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Herbert McKennis, Edward R. Bowman, Lennox B. Turnbull. The Isolation and Structure of a Ketoamide Formed in the Metabolism of Nicotine 1. Journal of the American Chemical Society. 1960-08, 82 (15): 3974–3976 [2022-01-14]. ISSN 0002-7863. doi:10.1021/ja01500a045. (原始内容存档于2022-01-15) (英语). 
  2. ^ Wakuluk-Machado, Anne-Marie; Dewez, Damien F.; Baguia, Hajar; Imbratta, Miguel; Echeverria, Pierre-Georges; Evano, Gwilherm. Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide. Organic Process Research & Development (American Chemical Society (ACS)). 2019-12-19, 24 (5): 713–723. ISSN 1083-6160. doi:10.1021/acs.oprd.9b00402. 
  3. ^ Pranjal K. Baruah, Jason Dinsmore, Amber M. King, Christophe Salomé, Marc De Ryck, Rafal Kaminski, Laurent Provins, Harold Kohn. Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 2012-06, 20 (11): 3551–3564 [2022-01-14]. doi:10.1016/j.bmc.2012.04.002. (原始内容存档于2018-06-30) (英语). 
  4. ^ Qiang Feng, Qiuling Song. Aldehydes and Ketones Formation: Copper-Catalyzed Aerobic Oxidative Decarboxylation of Phenylacetic Acids and α-Hydroxyphenylacetic Acids. The Journal of Organic Chemistry. 2014-02-21, 79 (4): 1867–1871 [2022-01-14]. ISSN 0022-3263. doi:10.1021/jo402778p. (原始内容存档于2022-01-14) (英语).