2-氰基-3-(4-甲基苯基)丙烯酸甲酯

2-氰基-3-(4-甲基苯基)丙烯酸甲酯是一种有机化合物,化学式为C12H11NO2。它可由氰乙酸甲酯4-甲基苯甲醛Knoevenagel缩合反应制得。[3]金雞納碱衍生的硫脲催化下,它和过氧化叔丁醇在−20 °C反应,得到环氧化物(2-氰基-3-(4-甲基苯基)环氧丙酸甲酯)。[4]

2-氰基-3-(4-甲基苯基)丙烯酸甲酯
别名 α-氰基-p-甲基肉桂酸甲酯
氰基(4-甲基亚苄基)乙酸甲酯
识别
CAS号 65576-65-0  checkY
13432-70-7E checkY
151887-71-7Z checkY
性质
化学式 C12H11NO2
摩尔质量 201.22 g·mol−1
外观 白色固体(E[1]
熔点 92 °C(365 K)(E[2]
92—93 °C(365—366 K)(E[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 Hao Xu, Liyang Pan, Xiaomin Fang, Baoying Liu, Wenkai Zhang, Minghua Lu, Yuanqing Xu, Tao Ding, Haibo Chang. Knoevenagel condensation catalyzed by novel Nmm-based ionic liquids in water. Tetrahedron Letters. 2017-06, 58 (24): 2360–2365 [2023-02-21]. doi:10.1016/j.tetlet.2017.05.006. (原始内容存档于2022-10-23) (英语). . Supporting Information (doc)页面存档备份,存于互联网档案馆
  2. ^ Jamal Lasri, M. Adília Januário Charmier, Matti Haukka, Armando J. L. Pombeiro. Stereospecific Synthesis of Polysubstituted E -Olefins by Reaction of Acyclic Nitrones with Free and Platinum(II) Coordinated Organonitriles. The Journal of Organic Chemistry. 2007-02-01, 72 (3): 750–755 [2023-02-21]. ISSN 0022-3263. doi:10.1021/jo061659b. (原始内容存档于2023-02-21) (英语). 
  3. ^ Stéphane Chalais, Pierre Laszlo, Arthur Mathy. Catalysis of the knoevenagel condensation. Tetrahedron Letters. 1985-01, 26 (37): 4453–4454 [2023-02-21]. doi:10.1016/S0040-4039(00)88928-5. (原始内容存档于2018-06-22) (英语). 
  4. ^ Sara Meninno, Luca Zullo, Jacob Overgaard, Alessandra Lattanzi. Tunable Cinchona -Based Thioureas-Catalysed Asymmetric Epoxidation to Synthetically Important Glycidic Ester Derivatives. Advanced Synthesis & Catalysis. 2017-03-20, 359 (6): 913–918 [2023-02-21]. doi:10.1002/adsc.201700146. (原始内容存档于2023-02-21) (英语).