2-哌啶甲酸

2-哌啶甲酸是一种有机化合物,化学式为C6H11NO2,可溶于水。[2]

2-哌啶甲酸
IUPAC名
piperidine-2-carboxylic acid
别名 哌啶-2-甲酸
识别
CAS号 535-75-1  checkY
3105-95-1(2S checkY
1723-00-8(2R checkY
PubChem 849
ChemSpider 826
SMILES
 
  • C1CCNC(C1)C(=O)O
InChI
 
  • 1/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)
InChIKey HXEACLLIILLPRG-UHFFFAOYAL
EINECS 217-024-4
ChEBI 17964
KEGG C00408
MeSH C031345
性质
化学式 C6H11NO2
摩尔质量 129.15704 g·mol⁻¹
熔点 266 °C(分解)[1]
溶解性 18.5 g/100 mL(25 °C)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

制备

2-哌啶甲酸可由2-吡啶甲酸在贵金属催化下的加氢反应得到。[3][4]

用途

2-哌啶甲酸可用于合成麻醉药盐酸布比卡因[5]

参考文献

  1. ^ Wolfgang Leithe. The configuration of optically active coniine and α-pipecoline. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen, 1932. 65B: 927-931. ISSN: 0365-9488.
  2. ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2019 ACD/Labs). Retrieved from SciFinder. [2019-3-22]
  3. ^ Muhammed Irfan, Elena Petricci, Toma N. Glasnov, Maurizio Taddei, C. Oliver Kappe. Continuous Flow Hydrogenation of Functionalized Pyridines. European Journal of Organic Chemistry. 2009-03, 2009 (9): 1327–1334 [2019-03-22]. doi:10.1002/ejoc.200801131. (原始内容存档于2019-08-21) (英语). 
  4. ^ Karpov, A. A.; Krasnikov, S. V.; Betnev, A. F.; Krasovskaya, G. G.; Chal'tsev, A. V. Catalytic hydrogenation of 2-furan- and 2- and 3-pyridinecarboxylic acids(俄文). Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 2007. 50 (4): 44-46. ISSN:0579-2991.
  5. ^ 胡艾希, 蒋瑶, 叶姣, 等. 三光气法合成盐酸布比卡因[J]. 药学进展, 2006, 30(2).